If you’ve ever been told that your TSH is too high, chances are you’ve been handed a prescription for levothyroxine and sent on your way. End of story. But what if you’re looking for ways to support your thyroid naturally – can you really lower TSH without medication?
When I was first diagnosed with Hashimoto’s and subclinical hypothyroidism, I not only wanted to feel better, but I was also hoping to reduce my TSH naturally; however, I didn’t have much success.
To be honest, for many years, I was quite skeptical that it could be done without taking external thyroid hormones.
But over the years, I’ve worked with thousands of people with Hashimoto’s and hypothyroidism and have kept an eye on emerging research and trends. I’ve seen firsthand that TSH levels can be normalized not just from medication, but from targeted supplements and diet/lifestyle interventions!
Now, before we dive in, I want to be clear: lowering TSH shouldn’t be the only goal. A low TSH doesn’t always mean you feel better – what really matters is supporting your body so you feel your best, and not everyone is a candidate for natural ways to lower TSH. That said, I wanted to share some of my latest discoveries with you.
TSH, or thyroid stimulating hormone, is a pituitary hormone that responds to low/high amounts of circulating thyroid hormone. The TSH test is used as a screening test for thyroid disease, as elevated TSH levels indicate hypothyroidism.
I still have an old lab report showing my TSH at 4.5 μIU/mL, along with a note written on it from my doctor. It said, “Your thyroid function is normal. No need to do anything.” Yet I felt terrible at the time. I share this story a lot, as so many people have been through the same thing.
You may feel fatigued, you may be consistently gaining weight, or you may be in a constant state of brain fog… but when you get tested, your TSH results come back shy of the 8 to 10 μIU/mL that is considered “abnormally elevated” on standard lab reference ranges. Your thyroid will be deemed “normal,” so many conventional doctors will not treat you with thyroid hormones or other thyroid health interventions. Some may even pull out the prescription pad and recommend something to calm your worries.
Welcome to the world of subclinical hypothyroidism, where TSH labs between 2 and 10 μIU/mL are viewed as “normal” by many conventional practitioners, and T4/T3 levels are usually within normal range.
Functional medicine practitioners, on the other hand, have defined “normal” TSH as between 1 and 2 μIU/mL (for a healthy person not taking thyroid hormone medications).
In my clinical practice, treating thousands of clients, I have personally found that most people feel best with a TSH between 0.5 and 2.0 μIU/mL, and are symptomatic with a TSH above 2.5 μIU/mL.
While the most effective way to reduce TSH is through taking the right type and dose of thyroid hormones, for some people — especially those with subclinical hypothyroidism and who may not yet be receiving treatment from a doctor — there are natural treatments available that have been shown to reduce TSH and improve well-being.
Other people may benefit from these same natural therapies in conjunction with taking their thyroid hormone medication. Of course, if you will be using natural therapies with medications, it’s always important to test your thyroid function to ensure you don’t become over-medicated!
In today’s article, you will discover:
- How elevated TSH is conventionally treated
- Natural treatments to lower TSH levels
- The importance of monitoring your thyroid hormones
- The need to address autoimmune triggers
How Elevated TSH is Conventionally Treated
Most conventional doctors test a patient’s TSH as part of routine lab testing (during an annual exam or as a response to symptom complaints). They may also test T4 levels (which is the amount of thyroid hormone circulating in the blood). But many use outdated reference ranges to determine what is “normal,” instead of using the more “optimal” ranges that functional doctors use.
As mentioned earlier, some integrative medicine clinicians have defined optimal TSH ranges as between 1 and 2 μIU/mL, which are significantly lower than many labs’ reference ranges, and some people feel better when their TSH is even lower. In a 2015 survey I did of 2,232 readers, over 69 percent of respondents said they felt better when their TSH was less than 1 μIU/mL! In my experience, most people feel best with a TSH between 0.5 and 2 μIU/mL, so I consider this to be the “optimal” reference range for most.
That being said, conventional medicine reference ranges are going to be much more lax, and in many cases, TSH labs that fall between 2 and 10 μIU/mL are viewed as “subclincal” by many conventional practitioners, and thyroid hormone medications are seldom prescribed unless TSH levels are above 10 μIU/mL, or if a woman is trying to conceive.
I think a big part of this is because many studies focused on treating “subclinical hypothyroid” patients with levothyroxine have found no improvement in symptoms. Of course, if you’ve been following me for some time, you will know that T4 medications simply don’t work as well as T3-containing meds for many thyroid patients.
In some cases, doctors will prescribe thyroid hormones if their patient is deemed “symptomatic,” but many obvious thyroid symptoms (obvious to me, but maybe not to conventional medicine practitioners) such as depression, anxiety, and fatigue, are brushed off as “psychiatric issues.”
Antibody testing is infrequently done by conventional practitioners, even though elevated antibodies can point to autoimmune issues years – even a decade – before a patient’s TSH is finally elevated to a number that can no longer be ignored. In the meantime, patients’ thyroids are working overtime to keep up, and thyroid damage is likely being done.
This is why it’s important to monitor your labs and understand optimal levels.
Thyroid medications, whether in the form of T4, T3, or combination formulas, can be a game-changer for many people with Hashimoto’s, and I do support their use in many cases. However, there are some cases where natural solutions can be a helpful alternative or addition to thyroid medications for certain individuals, such as those with TSH levels in the 2 to 10 μIU/mL range (considered subclinical hypothyroidism). Where medications are not yet prescribed, there are some natural solutions that can help lower TSH levels and, in some cases, even prevent the need for thyroid medications.
For other people with more advanced forms of hypothyroidism who are already on thyroid medications, these solutions may help lower TSH levels and relieve some of the symptoms associated with the condition.
Understanding Your Options: Different Guidelines for Different People
It’s important to understand that the interventions I will cover in this article will not be appropriate for everyone, so be sure to read through this list to determine which of these situations apply to you.
- People with Subclinical Hypothyroidism: For people with TSH levels in the 2-10 μIU/mL range and who are not yet on thyroid medications, natural solutions can help lower TSH levels and, in some cases, even prevent the need for prescription medications in the future.
- People On Medications, but Wanting to Try Alternatives: People who are on thyroid medications, but who wish to come off their prescriptions, or add alternative treatments to improve thyroid hormone levels and symptoms, may find natural options helpful. However, these people will need extra monitoring of their thyroid levels to ensure that they are not overmedicated during this transition (which can lead to hyperthyroidism).
- Women Who Are Trying to Conceive, Pregnant, or Breastfeeding: I generally recommend appropriate thyroid medications in these cases, as getting that TSH just right can be the difference between a healthy baby and a miscarriage, or a baby born with disabilities. 🙁 Women may also consider adding in some of the interventions that are known to be safe in pregnant or breastfeeding women, such as selenium, myo-inositol, and the gluten-free diet, under the supervision of your obstetrician. Please note that many of the other interventions shared in this article have not been studied in fertility, pregnancy, and lactation.
- People Without a Thyroid: People who have had their thyroids surgically removed will need to stay on thyroid medications. Because they are no longer able to produce their own thyroid hormones, they are unable to wean themselves off of medications with natural solutions, and will need to continue to take their medications for the long term. I have been in touch with some companies who are trying to change that, but the evidence is still pre-clinical. I will keep you posted when I learn more.
- People Who Are Sensitive/Reactive to Thyroid Medications: People who are sensitive to thyroid medications, or the fillers contained in many of them, or who have had adverse reactions to their medications, may benefit from using natural treatments as an alternate way to lower TSH levels and support their symptoms. I would also love to mention that there are hypoallergenic options like Tirosint that may be better tolerated, and there is an ultra-low dose desensitization protocol as detailed in my Optimizing Thyroid Medications eBook that may work for some. Also consider that sometimes liver congestion/gut infections can be the culprit behind the various sensitivities.
Diets to Reverse Hypothyroidism and Support Symptoms
Diet can have a major impact on thyroid health, and is usually the first place I begin when making lifestyle adjustments to heal Hashimoto’s naturally. There are three diets that have been shown to normalize thyroid function in some individuals.
1. Gluten-Free Diet
Around 43 percent of people with Hashimoto’s also have celiac disease, and in my experience, these are often the clients who can wean off thyroid meds, once they get off gluten for 3 to 6 months. Research supports this conclusion, showing that 19 percent of people with hypothyroidism who follow a gluten-free diet and also have celiac disease may be able to normalize their thyroid function. [1]
Additionally, 88 percent of people with Hashimoto’s may also be gluten-sensitive and may feel much better on a gluten-free diet. While it’s uncommon for people without celiac disease to completely stop taking thyroid medication solely by going gluten free, some do find they can reduce their dosage through a gluten-free diet. I believe this is likely due to better gastrointestinal function, which may help with medication absorption.
For more information on how a gluten-free diet can be beneficial for Hashimoto’s, please read my full article on the topic.
2. Further Elimination Diets
Beyond trying the gluten-free diet, I’ve also had some people who were able to improve or restore their thyroid function by going dairy free. In some cases, this resulted in better medication absorption after the inflammatory food was removed; in other cases, there was a complete restoration of thyroid function.
In people without celiac disease, I’ve also seen them eliminate their need for meds by following a gluten-, dairy-, and soy-free diet. That said, while most feel better, and some do improve TSH following an elimination diet to identify their exact food sensitivities, it’s not a guarantee.
3. High Iodine vs. Low Iodine
Iodine is a controversial topic in the thyroid world, with some experts advocating for high-dose iodine, while others advocating for low-dose iodine in healing the thyroid. In trying to figure it out for myself, I dove into the published research and found that the research was more supportive of iodine being a narrow therapeutic index nutrient for thyroid disease, with deficiency-induced hypothyroidism happening at one end of the spectrum, and autoimmune thyroid disease happening from excessive doses. [2] I came across a small 2003 study of 45 Korean patients with Hashimoto’s hypothyroidism that asked 23 of the patients to restrict iodine intake to <100 mcg per day, while 22 patients served as the control group. [3]
The article found that after three months, recovery to the euthyroid state was found in 78.3 percent of the iodine restriction group (18 out of 23 patients). Also, 45.5 percent of those from the second group also recovered thyroid function without iodine restriction (10 out of 22 patients). The researchers concluded that people who were most likely to benefit were those who had high baseline iodine intake and had Hashimoto’s for a shorter time. I don’t think it was the best designed study, as the groups had much different TSH levels at the beginning, so they were not true “controls,” and I don’t believe it was randomized. Additionally, the definition of “euthyroidism” was a TSH of 3.18 +/- 1.22 units, which in my opinion is a bit too high.
Furthermore, South Korea and many other Asian countries have a higher iodine intake compared to the US (500 to 1,100 mcg/day and sometimes even higher in coastal areas in South Korea, versus 150 to 250 mcg in the US).
Koreans consume large amounts of seaweed (kelp, wakame, gim), which is naturally rich in iodine. Seaweed soup (miyeokguk) is a traditional staple – especially postpartum and during illness.
That said, it does sound promising, especially for people who have been hypothyroid for a short period of time or who can trace the worsening of their condition to a time of excess iodine intake. You can actually view the full study via this link, as it’s publicly available.
I tried this approach in my earlier journey, but didn’t really see a big impact in my own health. I also recommended it as a temporary measure for three months following an acute iodine intoxication. I have had a few clients come to me after having adverse reactions from megadose iodine (above 500 mcg per day), seeing antibodies jumping from the 100s to 1000s, having TSH jump to 100 from the subclinical range, and experiencing debilitating symptoms. In that client population, the low iodine approach, coupled with other interventions I use, has indeed brought TSH levels, antibodies, and symptoms down.
I initially had this protocol in my head for people with known high iodine exposure; however, five years ago, my colleague Dr. Alan Christianson started using the low iodine approach with people with Hashimoto’s, with promising results (even with many of the individuals not having known excess iodine intake). He reports that many of his clients are able to wean off thyroid medications using this approach. An interesting fact I learned from him was that some personal care products may actually contain iodine, which can be topically absorbed. I also learned that pink Himalayan salt may have iodine as well (he recommends using gray sea salt instead). He recently published a book called The Thyroid Reset Diet, and I have an upcoming interview on my podcast with him going into the details of his protocol and experience (subscribe on Apple Podcasts or on Spotify to be notified when it comes out). Just to be clear, due to the importance of iodine in fertility and baby’s health, I do not recommend the low iodine diet for those who are trying to conceive, pregnant, or currently breastfeeding; rather, I recommend taking a prenatal with iodine (the typical dose is 150 to 250 mcg in most prenatals).
For more information on iodine and Hashimoto’s, please take a look at my article.
Natural Treatments to Lower TSH
Now, let’s take a look at the many natural treatments that are available to lower your TSH. I’ll share briefly about my own clinical experience with such treatments, as well as the available research. In many cases, I have also provided links to more detailed articles on my blog, focused on individual treatments.
For those of you who have already been prescribed hormone medication, you will want to be sure to monitor your thyroid labs every six to 12 weeks while using these interventions, to determine if they are effective (as well as adjust your dosage if needed, as these interventions can result in your needing less hormone medication).
4. Natural Desiccated Thyroid Medication
Natural Desiccated Thyroid (NDT) is a prescription thyroid medication that contains active thyroid hormones (T4 and T3). While it is a prescription hormone treatment, I am including it in this article, as it is a natural alternative to synthetic hormones.
NDT (also referred to as desiccated thyroid extract or DTE) contains bioidentical hormones isolated from the thyroid glands of pigs. Bioidentical hormones are natural and identical to what our own body would normally produce, just animal-derived. Two of the more popular NDT prescriptions out there are Armour® Thyroid and NP Thyroid.
Advocates of NDT feel that their natural sourcing may bring additional benefits such as trace amounts of other beneficial hormones like T1 and T2. Others disagree, given that NDT hormones may contain TPO and thyroglobulin from animal thyroids (which some people feel could actually worsen the autoimmune response).
That said, I’ve had good luck with them for most people. Research supports that 5 to 10 percent of people taking synthetic T4 medications – even if they are able to normalize their TSH – are still unhappy with how they feel. [4] Furthermore, sometimes people may have issues converting their thyroid hormones (T4 to T3) due to impaired liver or gut activity, nutrient deficiencies, infections, or stress; this can result in lingering symptoms when taking T4-only medication. (You can read more about some of the challenges with different T4 medications here.)
In such cases, I will often recommend NDT hormones to my clients if their synthetic T4 medication isn’t resolving all of their symptoms.
You may find it difficult to get an NDT prescription from a conventional doctor due to the history of NDT medications. But suffice it to say, things have changed a lot since then.
In my reader’s survey, 59 percent of respondents said they felt better using Armour Thyroid, and 59 percent said it improved their thyroid lab results. Research has also found that combination T4/T3 therapy establishes normal serum TSH levels and improvements in psychological parameters (a common issue with T4 dissatisfaction). One study comparing T4 therapy to desiccated thyroid, in which both control and treatment groups had a normal TSH, found that 48 percent preferred desiccated thyroid (versus 18.6 percent preferring the T4). [5] There are other clinical trials showing the preference for combination therapy when utilizing self-evaluation and quality of life questionnaires. [6]
You can read more about the pros and cons of different thyroid medications here.
This is prescription medication, so you will need to work with a practitioner. I suggest you find a good functional practitioner who has experience with NDT medications and who can carefully titrate your optimal dose.
Precautions: Although most negative side effects with NDT medications have to do with incorrect dosage, your doctor should evaluate your health history to determine any contraindications. T3 is considered a “fast release” medication and is absorbed very rapidly; this can sometimes cause cardiac-related symptoms (such as palpitations) and hyperthyroidism.
5. Aloe Vera
Aloe vera (Aloe barbadensis) is a well-known medicinal and nutrient-rich powerhouse loaded with vitamins (A, C and E, and essential B vitamins), along with many minerals vital for healthy T4 to T3 hormone conversion, including selenium, zinc, magnesium, chromium, copper, potassium, sodium, and calcium. Many of these are common nutrient deficiencies found in Hashimoto’s.
Research has shown that aloe vera is anti-inflammatory, adaptogenic (helping with our stress response), antibacterial and antiviral (important, as we know many infections are triggers for autoimmunity), supportive of digestive system health (partly due to its high enzyme content), protective of the liver, and possibly beneficial for those with impaired blood glucose control and insulin sensitivity. [7]
It is also useful for addressing acid reflux, a symptom that is common in those with hypothyroidism and Hashimoto’s, and one that I personally had for years. [8]
Furthermore, aloe vera has been found to have immune-modulating benefits which decrease thyroid inflammation, resulting in greater T4 secretion.
Aloe vera was shown to decrease TSH by 54 percent (as well as decrease TPO antibodies and increase serum-free T4) in one nine-month study (using a juice form of the Aloe barbadensismiller plant). [9] Thirty women were enrolled in the treatment group along with a control group of 15; the 30 women each had Hashimoto’s thyroiditis-related subclinical hypothyroidism (TSH > 4.0 mU/L) and were not taking T4 hormone medication (levothyroxine) at the time.
TSH levels decreased, and euthyroidism (defined as TSH < 4.0 mU/L) was achieved by 100 percent of women in the aloe vera treatment group!
All control group women, however, retained their subclinical hypothyroidism status (TSH > 4.0 mU/L).
Interestingly, the researcher who designed this study was a thyroid patient who found unexpected thyroid benefits after drinking aloe vera for skin benefits. 🙂
Given the many benefits of aloe vera, you may wish to give the liquid a try. And if you’re like me and have an unfortunate vomit response whenever I personally try to drink aloe vera, you may wish to try a capsule version, such as Aloe by Rootcology, which I created as an alternative to the liquid.
Precautions: Aloe may be contraindicated for certain medications and conditions. You can find important precaution information as well as additional details on health benefits, in my previous article on aloe vera.
6. Ashwagandha
Ashwagandha (Withania somnifera) is one of my favorite adaptogens for people with Hashimoto’s (who often experience stress and adrenal dysfunction as an underlying trigger).
Adaptogens normalize the hypothalamic-pituitary-adrenal (HPA) axis, meaning they boost underactive systems while they can also tone down overactive ones. They can really help improve our overall stress response (our ability to deal with whatever life throws at us).
As an adaptogen, ashwagandha contains many anti-stress and anti-inflammatory properties. In my reader survey, 47 percent of respondents said they felt better after taking adaptogens, 77 percent said they improved their mood, 78 percent said they improved their energy, and 15 percent said they improved their thyroid labs.
Ashwagandha has a naturally calming effect, and many of my clients experiencing fatigue have found it helps them get a better night’s sleep, as well as improve their mood. Ashwagandha has also been found to normalize thyroid hormone levels. One small study looked at 50 people with subclinical hypothyroidism with TSH levels between 4.5 and 10 μIU/L. The results showed that after eight weeks of treatment, ashwagandha improved and normalized serum TSH (improved by 19 percent), T3 (improved by 21 percent), and T4 (improved by 45 percent) serum levels. [10]
In my clinical practice, I have seen ashwagandha help normalize TSH and other thyroid hormone levels in clients with subclinical hypothyroidism.
I have used ashwagandha and other adaptogens myself for many years, especially when I have been under writing deadlines and feeling overly stressed. I did take a break from them while pregnant, but now do take them regularly again (and am enjoying doing so).
Because ashwagandha has been so supportive for me and my clients, I included it as a key ingredient in my adrenal support blend, Rootcology Adrenal Support.
However, if you are looking for a stand-alone ashwagandha supplement, Ashwagandha by Pure Encapsulations is a high-quality choice.
Precautions: Ashwagandha should not be taken by pregnant or lactating women. People taking thyroid hormone medications, immunosuppressant medications, blood thinners, or sedatives should consult with their practitioner in regards to any potential contrary effects. Ashwagandha may be contraindicated for individuals with allergies to nightshades (bell peppers, eggplant, cayenne pepper, white potatoes, tomatoes, etc.).
7. Myo-inositol
Myo-inositol is another beneficial nutrient that I often recommend in my clinical practice. It has anti-inflammatory, anti-diabetic, antioxidant, and anticancer effects. [11] Myo-inositol is a form of inositol, a type of natural sugar alcohol that is present in mammalian cells.
I often recommend myo-inositol, taken along with selenium (another extremely beneficial thyroid nutrient), as an initial thyroid cocktail combination to address subclinical hypothyroidism. (Many people are deficient in both of these nutrients.)
One 2013 study found that subclinical hypothyroidism patients given a combination of myo-inositol and selenium had a decrease in both thyroid antibodies as well as a 31 percent reduction in their TSH levels, restoring the euthyroid state. Selenium alone did not result in decreases in TSH. [12] The findings of that study were later reconfirmed in 2017. [13]
Myo-inositol has other significant benefits: it regulates glucose uptake and has been shown to improve symptoms associated with mood swings, anxiety, depression, and OCD. (I have found that for some clients, having these types of symptoms is actually one of their initial signs of an autoimmune attack on their thyroid.) I have clients use it as a natural solution (versus psychiatric medications with many side effects) to OCD and anxiety.
A few years ago, I added a Selenium + Myo-Inositol product to my Rootcology product line, with the exact dosages of each nutrient used in the studies. I also offer a standalone Myo-Inositol Powder. My favorite way to use myo-inositol is to stir it into a cup of tea as a mild sweetener. 🙂
Precautions: Myo-inositol is generally not recommended if you are pregnant or lactating, though there are studies to support its use, especially in gestational diabetes, so please be sure to check with your doctor. Myo-inositol should not be taken by people who have kidney disease, nor by those who are taking diuretic medications, blood thinners, or supplements with diuretic properties (such as cleavers) that can affect the kidneys or the lymphatic system. People with diabetes should watch for signs of low blood sugar.
You can learn more about myo-inositol and selenium in these earlier articles.
8. LLLT (Low-Level Laser Therapy)
Low-level laser therapy (LLLT, also often called photobiomodulation or PBM therapy) is a safe, non-invasive, painless, and low-cost intervention that has been shown to reduce oxidative stress in the thyroid gland and to accelerate thyroid tissue healing. The research behind this therapy is excellent.
Numerous studies focused on hypothyroidism and Hashimoto’s have found that LLLT has resulted in: [14]
- A reduction in the required dose of T4 thyroid medication (Note: Some people were, in fact, able to stop taking their thyroid medication completely, and their thyroid function normalized!)
- Improvements in the autoimmune condition (i.e. a reduction in the autoimmune attack)
- A reduction in thyroid antibodies
- Normalization of thyroid size
For details of the research on the use of laser therapy, please check out the exciting results in this earlier article, here. Just as one highlight to mention, in one study, 95.7 percent of the treatment group was able to reduce or stop their thyroid hormone medications (with 47.8 percent no longer needing any thyroid medications) after LLLT. [15] That study also found an approximately 50 percent reduction in TPO antibodies and normalization of thyroid volume in 66 percent of the treatment group.
So you may wonder, why isn’t everyone out there getting laser therapy?
The caveat here is that the wonderful effects people see from low-level laser therapy don’t last forever; the results are temporary (typically 9 to 12 months, and then new LLLT sessions are required to maintain the results longer term). [16] Low-level laser therapy is also difficult to find here in the United States, where it is still viewed as experimental (versus in Europe or Brazil – much of the research is being done in Brazil).
With that said, this treatment can be extremely helpful for the right person. If you work to eliminate the autoimmune response in your body (by removing triggers), you can combine that with LLLT and, essentially, induce a functional cure for yourself where you no longer have the attack on the thyroid gland, you no longer have thyroid symptoms, and your thyroid gland is producing thyroid hormones on its own.
So how does LLLT work? It is a “cold laser” approach. It has been shown that tissue can regenerate when a laser is applied directly over a given organ. [17] The thyroid gland is a good candidate for LLLT, as it is close to the skin’s surface such that the laser can easily penetrate it.
Along with regenerating tissue, LLLT also increases circulation in the organ and appears to reduce the elevated levels of pro-inflammatory cytokines seen in autoimmune diseases. Furthermore, LLLT increases “good” immunomodulatory cytokines called Transforming Growth Factor B (TGF- β), that support the body’s tolerance of self and reduce thyroid autoimmunity. Reduced TGF- β levels have been found to be associated with Hashimoto’s. [18]
While lasers have the most research behind them, they’re also the least accessible. In contrast, LEDs are much more cost-effective and easy to use. That said, the evidence for red light therapy from LEDs is still anecdotal, as there have not been large clinical trials looking at how effective they are specifically.
In my personal experience, some of my readers have reported benefits from using at-home LED devices, and I think they’re worth trying!
Today there are a number of handheld devices (as well as other red light therapy products) on the market that are available for direct-to-consumer purchase and use. If you try one of these devices, please be sure to follow the instructions for the individual products, as usage will vary. Also please note that the effectiveness of a given unit may vary depending on its size and power, as well as on the length of treatment and how far away the light is from your skin.
Some of my favorites include Lumebox, Orion Pro 300, and the Go 2.0 from Joovv.
Precautions: You will want to work with a practitioner who is knowledgeable about using LLLT, specifically for thyroid conditions. If you have had your thyroid gland surgically removed or destroyed, or if you were born without a thyroid, LLLT is not likely to help your condition. There are no research studies relating to LLLT and those taking immune suppressants, those with thyroid nodules, those with Graves’ disease, or those with postpartum thyroiditis.
Anti-inflammatory medications may make LLLT less effective. Antioxidants such as selenium, vitamin C, and N-acetyl-cysteine (that are usually very helpful for Hashimoto’s) may negate the effects of LLLT as well. Check out my article on laser therapy for additional information.
9. Guggul
Guggul is the gum resin obtained from two different plants, Commiphora and Boswellia. It contains many phenolic compounds which possess substantial anti-inflammatory and antioxidant effects.
You’ve likely never heard of guggul (Google it! ;-)), but it has been found to provide support in a number of conditions, including acne, arthritis, IBD, diabetes, psoriasis, respiratory diseases, and even cancer. [19] Along with its anti-inflammatory effects, it has hepatoprotective (liver protective), cardioprotective, neuroprotective, and hypolipidemia (low blood lipid) properties as well.
In animal studies, it has been shown to exhibit a thyroid stimulatory effect, increasing thyroid hormone and improving overall thyroid function. [20] It targets multiple signaling pathways which appear to result in improving the activities of thyroid peroxidase and enhancing iodine uptake. Research with mice showed that it has the potential to ameliorate hypothyroidism. [21]
I created a multinutrient supplement to support T4 and T3 conversion, which includes guggul and ashwagandha, called Thyroid Conversion Support. You can also get each supplement as a standalone – Ashwagandha from Pure Encapsulations and Guggul from Himalaya Wellness (available via Fullscript; if you don’t have a Fullscript account, you can sign up with my credentials here).
Precautions: Guggul is not recommended if you are pregnant or lactating; it appears to stimulate the uterus and not enough is known about its safety. Guggul may have an estrogen-like effect on the body, so it may not be appropriate for people having certain hormone-sensitive conditions such as breast cancer. Please consult with your doctor before use.
10. Cordyceps
Cordyceps (Cordyceps sinensis) is one of my favorite supportive herbs (it is actually a fungus/mushroom that is now often synthetically produced), as it has many benefits for Hashimoto’s, including being anti-inflammatory, immune-modulating, antiviral, and antimicrobial. [22] I will often recommend cordyceps when a client has some type of viral infection, as well as for its health effects relating to supporting immune function, liver, kidney, and gut health.
Cordyceps is rich in selenium, which we know is a nutrient that has been shown to reduce thyroid antibody levels. [23] Not surprisingly, research has shown that cordyceps has the ability to decrease TSH and thyroid antibody levels, as well as result in improvements in the autoimmune condition. [24]
In one study, patients with significantly elevated thyroid antibody levels and impaired thyroid function (measured by TSH), as well as lower CD4+ T cells and higher CD8+ T cells (both associated with immune disorders), were treated with a drug derived from cordyceps, called Corbrin Capsule. With treatment, there was a decrease in CD8+ T cells (improving the autoimmune condition) and a significant drop in TPO antibodies and TSH. [25]
I like a product called Cordyceps by NOW.
Precautions: Cordyceps should not be taken by pregnant or lactating women. Cordyceps can interfere with blood clotting. People with existing autoimmune diseases (including multiple sclerosis, rheumatoid arthritis, and lupus) should consult with their physician, as cordyceps could interfere with medications, including blood thinners.
You can read more about cordyceps in this earlier article on the top herbs that are supportive of Hashimoto’s.
11. Probiotics
In my 2015 readers’ survey, 75 percent of respondents said they felt better when taking a probiotic. Some 51 percent said they had improved mood, 62 percent had improved energy, and 17 percent said that taking probiotics resulted in improved labs. Additionally, 57 percent of respondents said they felt better when eating fermented foods.
There are many reasons probiotics have been shown to help with hypothyroidism and Hashimoto’s symptoms. Studies have shown that probiotics may: [26]
- Limit pathogenic bacteria and improve overall microbiome diversity
- Influence the number of cytokines, decreasing pro-inflammatory and increasing anti-inflammatory levels (reducing overall inflammation)
- Improve intestinal barrier function (remember, one of the three requirements for having Hashimoto’s in the first place is intestinal barrier permeability or leaky gut), which helps support our immune system (of which about 70 percent can be found in our gut)
- Influence the nutrient absorption of key thyroid nutrients such as selenium
- Improve T4 to T3 thyroid hormone conversion
- Influence T4 metabolism and absorption
Regarding the last point, a 2017 study concluded that a specific combination of probiotic strains (Lactobacillus and Bifidobacteria) was able to improve T4 metabolism. [27] We know that T4 hormone medications are often negatively affected by metabolism and absorption challenges (such as when someone eats at the same time they take their thyroid meds, or if they take an acid reducer with their meds). While the study did not show significant improvements in thyroid hormone levels, the researchers found that the treatment group required a reduced dose of T4 medication when taking the probiotics, pointing to improved T4 metabolism and absorption.
I have found both low levels of beneficial probiotic bacteria such as these, as well as high levels of opportunistic bacteria such as E. coli, on many clients’ GI-MAP and GI Effects lab tests (as well as on my own lab tests in the past).
Years ago, I took my first stool test and was quite surprised at the findings of having no beneficial Lactobacillus bacteria at all, even though I had been eating probiotic yogurts at the time. It wasn’t until I added probiotic supplementation as well as started to eat fermented foods, that I optimized the beneficial bacteria in my gut and started to feel so much better.
Two-thirds of our bacteria is found in our gut, and research has found that the gut microbiome plays a significant role in metabolic functions, nutrient absorption, and immunologic support. [28] An impaired gut has been found to affect poor nutrient absorption of key thyroid-supportive nutrients such as selenium, iron, and zinc. [29] This could result in an indirect effect on TSH and other thyroid hormone levels.
Of note, selenium is often found to be deficient in people with hypothyroidism, as selenium is needed to produce selenoproteins needed for proper thyroid function.
I typically recommend that all of my clients supplement with probiotics and/or eat fermented foods to support their microbiome and immune system and to optimize their thyroid medication. (Note: Those with small intestinal bacterial overgrowth, or SIBO, however, should avoid most probiotics.)
I have found that the ratio we want for optimal microbiome balance is about 85 percent beneficial to 15 percent potentially pathogenic bacteria. To maintain that balance, a therapeutic-dose, multiple-strain, and pharmaceutical-grade probiotic is the best solution.
You can learn about the top probiotics that I recommend at the linked to article, along with dosage info and precautions. Note that many probiotics contain dairy, gluten, or soy, so you do need to be careful that you know what you are taking, especially if you have known food sensitivities.
Even if taking a high-dose probiotic, I still love for people to bump up their fermented veggies. They are so beneficial and can really impact gut healing. In my book Hashimoto’s Food Pharmacology, I’ve included some of my favorite fermented foods, which you can easily make yourself.
12. Thytrophin PMG
Thytrophin PMG is made from a bovine thyroid extract along with a proprietary extract called protomorphogen (PMG). According to the manufacturer, Standard Process, the extract contains no glandular material. This means it contains no TPO or thyroglobulin, so it will not induce an autoimmune reaction against the thyroid gland.
Thytrophin PMG acts like a decoy of sorts by distracting the immune system from attacking the thyroid gland. It prompts the immune system to attack the Thytrophin PMG rather than its own thyroid gland. This gives the thyroid a break from ongoing attack, allowing it to regenerate.
I’ve seen people reduce their thyroid antibodies after about a month, with the supplement’s full effect seen in about three months. In the meantime, a person can be working on addressing their triggers, leaky gut, and other root causes. While the research is still in the early stages, I’ve seen some good benefits (and also feel it has a low potential to cause harm).
I have recommended Thytrophin PMG in combination with thyroid medications, as it has improved thyroid symptoms and reduced antibodies. Some people have been able to just use Thytrophin PMG instead of using thyroid hormone medication.
You do need to work with a practitioner, as Standard Process sells Thytrophin PMG to practitioners only; you can’t purchase this extract yourself or online.
I generally recommend taking up to nine tablets of Thytrophin PMG daily, with antibody testing following the initiation of treatment.
Precautions: Not certified as gluten- or dairy-free (their facility uses wheat germ in other products), although I haven’t seen any cross-reactivity concerns with my own clients’ use. It is animal-derived, which may cause a reaction in some people.
13. Systemic Enzymes
The immune system is very dependent on proper enzyme function to help regulate inflammation, as well as protect cells from damage. One enzyme I have used since 2013 has shown wonderful results in improving thyroid function.
Wobenzym® is a systemic enzyme formulation that has been clinically studied for supporting numerous processes in the body, including thyroid health.
It has been found to be effective at reducing inflammation as well as reducing (and sometimes eliminating) thyroid antibodies. People using Wobenzym have seen improvement in thyroid function and subjective symptoms as well.
In one three-month study, 20 patients taking Wobenzym along with levothyroxine treatment showed a significant decrease in both TPO and TG antibodies. [30] They also had a decrease in triglyceride and cholesterol levels, as well as an improvement in thyroid symptoms. The control group patients taking only levothyroxine showed no significant changes.
Additionally, those taking Wobenzym could lower their dosage requirement for levothyroxine after the initial three months; in some cases, they could discontinue hormone treatment completely. (Note that while Wobenzym N is the formulation that was part of this study, I’ve personally seen similar clinical benefits with Wobenzym PS as well.)
Similar results were found in a 2015 study. In this study, 45 patients with autoimmune thyroiditis were divided into three groups, for a period of six months. [31] One group consisted of Wobenzym treatment alone. Another consisted of Wobenzym treatment along with thyroid hormone medication. The third group consisted of thyroid hormones alone.
Treatment with thyroid hormones, in combination with Wobenzym or alone, significantly decreased TSH levels, while Wobenzym alone did not. However, TSH values decreased to a higher degree with the combined (Wobenzym and hormone) treatment (versus hormones alone), suggesting that thyroid hormone medication could be reduced.
I love systemic enzymes so much that I added them to my Rootcology product line. One of the concerns I had with the products on the market was that they required a LOT of tablets to be taken per day (around five, three times per day on an empty stomach). I learned about different formulations and came across a version that could be helpful with just two capsules per day, and that’s how Rootcology Systemic Enzymes was born!
Precautions: Systemic enzymes should not be taken by pregnant or lactating women, or people who suffer from bleeding disorders or liver damage. Systemic enzymes can interfere with blood clotting so it should not be taken with blood thinners.
For more information, please see my earlier article on Wobenzym or download the free 2017 eBook on Wobenzym, written by the late Dr. Joseph J. Collins (President and Co-founder of Your Hormones, Inc.). However, please note that Wobenzym is currently experiencing a shortage as of Apr 2025, so Rootcology Systemic Enzymes is a great alternative.
14. Thyroid Glandulars
Thyroid glandulars are supplements that contain thyroid gland tissue from animals but are not supposed to contain active thyroid hormones. Thyroid Natural Glandular by Allergy Research Group is one product that I am familiar with. However, there are many different forms of glandular supplements available.
Some people may choose to use thyroid glandular supplements based on the theory that “like heals like.” The idea is that, if you have a thyroid issue, then taking a thyroid gland supplement could help heal your own thyroid. This approach is not new; ingesting different parts of an animal to help heal that part of the human body, has been used throughout human history. (Its origins can be traced back to ancient Greek, ancient Egyptian, and traditional Chinese medicine practices.) For example, if a doctor thought you had a liver problem, he may have recommended consuming animal liver to help your own liver heal.
Over-the-counter options may be especially interesting for patients who are unable to find doctors to prescribe NDT medications, those with only a slight elevation in TSH, or those who do not tolerate thyroid medications. That said, many practitioners advise against using over-the-counter glandular tissues, as they are not well regulated and, while they are not supposed to contain thyroid hormones, some still do. This can result in a person unknowingly taking in thyroid hormones in varying quantities, which could lead to further deregulation of thyroid hormones circulating in a person’s body.
While easy to confuse with thyroid glandulars, Natural Desiccated Thyroid (NDT) medications are prescription medications that contain measured amounts of thyroid hormones from animal sources. For most, NDT medications are recommended above over-the-counter glandular supplements, as they are regulated and dosed by a practitioner and tightly regulated to contain the exact thyroid hormones they say they have. To be fully transparent, I prefer the prescription thyroid hormones, because they allow for better control and dosing. I have personally consulted with many clients who were on over-the-counter glandulars and struggled to get balanced.
However, if you are working with a knowledgeable professional who can guide you, perhaps you might have different results. Some colleagues have reported that utilizing these products for a six- to 12-month period allowed their clients to normalize their TSH and subsequently discontinue the glandular while their thyroid hormone levels remained optimal. If you know a thyroid glandular expert, I would love to interview them to learn more. For now, I am hesitant to recommend them.
Precautions: Note that with thyroid glandulars, there is potential for dosing issues given that thyroid glands are being used. Thyroid hormones are goldilocks hormones, meaning too much or too little can be a significant issue. As such, there is a potential for overdose if you take the wrong dose or use an impure product containing actual hormones. It shouldn’t be combined with thyroid medications, either.
My concern with these extracts is that they are not regulated, and some T4 or T3 hormones may find their way into the final product either accidentally or intentionally. Therefore, I highly recommend anyone wanting to try them, to work with a practitioner who is familiar with using them (and who likely has a favorite they feel comfortable with in terms of quality and purity).
15. Black Seed Oil
Black seed oil (derived from black cumin, or Nigella sativa) has been studied relating to its many properties, including being antimicrobial, antioxidant, immunomodulatory, anti-inflammatory, anticancer, gastroprotective, hepatoprotective (liver protective), and antidiabetic. [32] Most of its significant effects are provided by one primary bioactive component called thymoquinone.
Many people use black seed oil for non-thyroid-specific conditions such as joint inflammation. But, I have also found it to be a great natural therapy for people with Hashimoto’s.
Most people with Hashimoto’s have a congested liver, and black seed oil has been shown to prevent liver toxicities such as those resulting from heavy metals.
It also has antimicrobial properties and is effective against another common Hashimoto’s trigger, the H. pylori infection. I safely used black seed oil after the birth of my son, as I had tested myself and found that I had H. pylori. I was able to clear up the infection and lowered my thyroid antibody levels, which had escalated after giving birth.
Black seed oil has also been shown to improve hypothyroidism labs and symptoms. In one study, researchers found that black seed oil ever so slightly improved TSH, T3, and thyroid antibody levels after just eight weeks. [33]
Participants between the ages of 22 and 50 received either 2 grams per day of black seed oil, or 2 grams per day of placebo, for eight weeks. Participants were also treated with levothyroxine from six weeks prior to the study, through the end of the trial.
At the beginning of the trial, there were no significant differences between the two groups. At the end of the eight-week trial, the group receiving the black seed oil saw a reduction in weight, as well as in waist and hip circumference, compared to the placebo group.
During the trial, serum thyroid stimulating hormone (TSH) levels were reduced from an average of 6.42 mIU/l to 4.13 mIU/l in the group receiving the black seed oil. Serum T3 also improved from an average of 0.92 mmol/l, to an average of 1.06 mmol/l. While these changes were small, they were found to be statistically significant.
I added Black Cumin Seed Extract to the Rootcology product line, which is an easy-to-take capsule. Black seed oil is also available as a liquid and in seed form.
Precautions: Before considering black seed oil, talk to your doctor if you have an underlying medical condition (such as diabetes, bleeding disorders, or low blood pressure), if you are taking medications, if you are pregnant or lactating, or if you have surgery planned.
See additional precaution info and research in this earlier article on black seed oil.
16. Vitamin A
While there are many important vitamins supportive of thyroid health that people are often deficient in, one particular vitamin tied to TSH levels is vitamin A.
In one 2012 study, vitamin A supplementation was found to significantly reduce serum TSH levels and increase T3 in premenopausal women. [34] Other research has confirmed vitamin A’s relationship with TSH levels and also found that vitamin A deficiency aggravates thyroid dysfunction as well as adversely affects thyroid metabolism, by reducing the intake of iodine by the thyroid gland and increasing the size of the thyroid gland. [35]
Along with being important for healthy thyroid function, vitamin A (retinol) and its components (such as retinoic acid) have a key role in immune system health, growth, metabolism, vision, brain functions, and tissue remodeling. [36]
Retinoic acid (RA) has also been found to inhibit the development of inflammatory cells and induce Tregs (a subpopulation of T cells that help maintain immune tolerance and regulate the autoimmune response). [37]
In the 2012 study, 84 premenopausal women were involved in a four-month randomized, double-blind controlled trial. Women were given vitamin A (25,000 IU/d retinyl palmitate) or a placebo. At the end of trial, women’s TSH slightly reduced from 3 to 2. While a very modest reduction in my opinion, the analysis did find this was statistically significant and that vitamin A had the potential to reduce the risk of subclinical hypothyroidism.
Vitamin A and thyroid hormones are intimately connected. We can get vitamin A through diet by eating foods containing beta-carotene (found most famously in carrots, but also in other plant sources). However, eating beta-carotene-containing foods alone doesn’t help with our vitamin A requirements; beta-carotene is inactive and must be converted into the active form, vitamin A (retinol). And what’s needed for this conversion? Thyroid hormone! So people with low thyroid hormone levels (hypothyroidism) will often be vitamin A deficient.
Interestingly, some people (including yours truly!) also have a specific gene variation that further reduces their ability to convert beta-carotene to vitamin A – one known variant to the BCMO1 gene. People with hypothyroidism and this gene variation are hit doubly hard in regards to not being able to convert beta-carotene into retinol. And if you also happen to be a vegetarian or vegan, you’ll be hit a third time, as you won’t be someone who eats animal-based sources of vitamin A.
Because I have this gene variant (and Hashimoto’s), I know I need to increase my animal-based vitamin A food sources such as liver, as well as take a supplement.
You can read about other gene variants relating to nutrients that affect hypothyroidism and Hashimoto’s at this link. I participated in this study, and it is fascinating to see how genetics can influence things like nutrient absorption (who knew I’d have a gene variation that affected my ability to get the nutrients out of carrots!). Remember, though, that genes are not our destiny when it comes to conditions such as Hashimoto’s. How we live our lives can influence how our genes get expressed.
As I mentioned above, beta carotene (a carotenoid) is the source of vitamin A that is found in plant products, while retinol palmitate (a retinoid) is found in animal products, such as eggs, chicken, and beef. Carotenoids are the pigments that give plants their color (such as carrots and peppers), but they are not bioavailable and must be converted in the body to retinoids. This process can be difficult for some individuals with health conditions and genetic variations. Retinoids from animal sources, however, are bioavailable and easily absorbed by the body.
Cod liver oil is one source of animal-derived retinol that is easily absorbed and comes packaged with other important nutrients, such as vitamin D and essential fatty acids. However, if you want a more precise dose of vitamin A, a standalone supplement might be preferable.
As far as supplement options, Klaire Labs Micellized Vitamin A contains at a dose of 1500 RAE per drop (vitamin A is now measured in mcg RAE), which is equivalent to 5000 IU per drop. For an individual to reach the 25,000 IU/day dosage (this converts to 7500 mcg RAE) demonstrated to have benefits in the 2012 study, they would have to consume five drops a day of the Klaire Labs Micellized Vitamin A.
I also added vitamin A to my new Rootcology product Thyroid Conversion Support, as part of a synergistic blend of thyroid-supportive vitamins and herbs.
Precautions: Because vitamin A is fat-soluble, it can accumulate in the body. High doses over time may lead to symptoms like dizziness, nausea, liver damage, or other serious health issues. Consult your doctor if you’re pregnant, as excessive vitamin A can cause birth defects. Consult your healthcare provider before starting supplementation.
Honorable Mention: Rhodiola
Lastly, I know that some people are looking for alternatives to thyroid medications because they can’t tolerate them or are having a hard time stabilizing on thyroid meds, and may be hypothyroid as a result, so I wanted to provide something that has been studied to potentially provide some relief. Though it hasn’t been necessarily found to lower TSH levels, the adaptogen rhodiola has been investigated as a viable alternative treatment for the symptoms of short-term hypothyroidism in patients with thyroid cancer who require hormone withdrawal. [38]
Rhodiola (Rhodiola rosea) is a common plant in traditional medical systems in Eastern Europe and Asia, often used for stimulating the nervous system, decreasing depression, enhancing work performance, and eliminating fatigue — common symptoms of hypothyroidism. [39]
Sometimes referred to as Golden Root, rhodiola is a versatile adaptogen that not only helps us maintain a healthy stress response, but has also been found to improve depressive symptoms, insomnia, low mood, and mood instability. It has a stimulatory effect on people in a state of fatigue. I think of rhodiola as the adaptogen focused on our nervous system health. In particular, I have found rhodiola to be helpful for my clients with depressed cortisol levels.
Researchers have also studied other benefits of rhodiola, such as cardioprotection or even tumor growth inhibition. [40] Studies suggest that rhodiola inhibits the breakdown of serotonin, dopamine, and norepinephrine, thus facilitating neurotransmitter transport through the brain. It also prevents the production of excess cortisol, which supports adrenal balance — a crucial piece of feeling well with a thyroid condition..
Rhodiola Rosea by Pure Encapsulations is a high-quality option.
Precautions: Rhodiola may be contraindicated for individuals taking antidepressant medications, as well as adrenergic-blocking and antiarrhythmic medications. Some people may react to its stimulatory effect and experience insomnia, headaches, irritability, or excitement.
The Importance Of Monitoring Thyroid Hormones
For those of you already on thyroid hormone medication, but who want to further support thyroid healing, I always encourage you to try these interventions along with addressing your autoimmune triggers such as diet, food sensitivities, stress, and infections.
You should always discuss supplementation – even natural treatment options – with your doctor, and also have your doctor monitor your labs along the way. Ideally, you’ve had your thyroid labs done recently (in the last three months) prior to starting new interventions.
As you improve your TSH, antibody levels, or general thyroid health, you may need to have your doctor reduce your thyroid hormone medication.
I recommend testing thyroid hormone levels every six to 12 weeks while using complementary therapies, including root cause medicine, diet, or supplements, to ensure your thyroid medication dosage is optimized, or sooner, if you are showing any of the symptoms of being overmedicated such as rapid or irregular heartbeat, nervousness, irritability or mood swings, muscle weakness or tremors, diarrhea, heat intolerance, menstrual irregularities, hair loss, weight loss, insomnia, chest pain, and/or excessive sweating.
Thyroid medications are goldilocks hormones – they need to be used in just the right dose – and there are risk factors of being overmedicated.
If you are trying to conceive, pregnant or lactating, or if you have an underlying health condition or are taking other medications, it is especially important to review any kind of supplementation with your doctor.
For those of you who are not taking hormone medication (or who may not have even seen a doctor as of yet), but have vague symptoms, a family history of thyroid problems, or have had labs done in the past (even if showing a “normal” TSH level), you might want to consider having a full thyroid panel done. Remember that while conventional doctors typically only look at TSH, or maybe T4 levels, functional practitioners will always look at other thyroid hormone markers (and at optimal levels) to make the most accurate assessment of thyroid health.
I recommend ordering a full thyroid panel (TSH, free T3, free T4, thyroid antibodies) and possibly a thyroid ultrasound.
While it is best to have a good functional doctor on your healthcare team, you can go ahead and self-order a thyroid panel. I’ve set up discounted tests that you can self-order with Ulta Labs, and they can be ordered anywhere in the US. You will receive a lab order that can be taken to your local lab, and the results will be sent to you. (Find more information on how to interpret your lab results in this article.)
The Need to Address Autoimmune Triggers (Along With Thyroid Hormones)
Hashimoto’s is an autoimmune disease, so optimizing your TSH levels is only part of the puzzle. If you have Hashimoto’s, you also need to address the autoimmune component of it. I will say, sometimes finding the cause, such as an infection or an infected tooth, can lower the TSH as well! I’ve seen this most commonly with H. pylori and sometimes with Blasto.
So it’s time to put on your detective cap and work to identify and remove your root cause triggers!
I’ve written an article that introduces people to the concept of finding the root causes of autoimmune disease such as Hashimoto’s. Reading this is a good place to start if you are just beginning your Hashimoto’s journey. Just take it slow and know that every small step you make towards improving your health will help you feel better.
There are many common triggers and a lot of helpful information on this blog. Food sensitivities, nutrient deficiencies, an impaired stress response, toxins, infections, and leaky gut are just a few that most people will want to focus on.
The good news? Many of these interventions have enormous positive results in a relatively small amount of time. For example, in my survey, 93 percent of respondents felt better just by going gluten-free, while 75 percent felt better on a dairy-free diet. Those are relatively easy changes to try out.
My book Hashimoto’s Protocol can also be a helpful resource. It focuses on helping you to identify and remove your own set of particular triggers.
I hope all this information helps you on your healing journey!
P.S. I love interacting with my readers on social media, and I encourage you to join my Facebook, Instagram, TikTok, and Pinterest community pages to stay on top of thyroid health updates and meet others who are following similar health journeys. For recipes, a FREE Thyroid Diet Quick Start Guide, and notifications about upcoming events, be sure to sign up for my email list!
References
[1] Sategna-Guidetti C, Volta U, Ciacci C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001;96(3):751-757. doi:10.1111/j.1572-0241.2001.03617.x
[2] Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis AG. Iodine-Induced hypothyroidism. Thyroid. 2001;11(5):501-510. doi:10.1089/105072501300176462
[3] Yoon SJ, Choi SR, Kim DM, et al. The effect of iodine restriction on thyroid function in patients with hypothyroidism due to Hashimoto’s thyroiditis. Yonsei Med J. 2003;44(2):227-235. doi:10.3349/ymj.2003.44.2.227
[4] Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014;24(12):1670-1751. doi:10.1089/thy.2014.0028
[5] Hoang TD, Olsen CH, Mai VQ, Clyde PW, Shakir MK. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab. 2013;98(5):1982-1990. doi:10.1210/jc.2012-4107
[6] McAninch EA, Bianco AC. The swinging pendulum in treatment for hypothyroidism: From (and toward?) combination therapy. Front Endocrinol (Lausanne). 2019;10:446.
[7] Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020;25(6):1324. Published 2020 Mar 13. doi:10.3390/molecules25061324; Shin E, Shim KS, Kong H, et al. Dietary Aloe improves insulin sensitivity via the suppression of obesity-induced inflammation in obese mice. Immune Netw. 2011;11(1):59-67.; Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, et al. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. J Diabetes Metab Disord. 2015;14:22. Published 2015 Apr 9. 015-0137-2.
[8] Gupta VK, Malhotra S. Pharmacological attribute of Aloe vera: revalidation through experimental and clinical studies. Ayu. 2012;33(2):193-196.
[9] Metro D, Cernaro V, Papa M, et al. Marked improvement of thyroid function and autoimmunity by Aloe barbadensis miller juice in patients with subclinical hypothyroidism. J Clin Transl Endocrinol. 2018;11:18-25. Published 2018 Feb 14.
[10] Sharma AK, Basu I, Singh S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. J Altern Complement Med. 2018;24(3):243-248. doi:10.1089/acm.2017.0183
[11] Dinicola S, Minini M, Unfer V, et al.. Nutritional and acquired deficiencies in Inositol bioavailability. Correlations with metabolic disorders. International Journal of Molecular Sciences. 2017;18(10):2187.
[12] Nordio M, Pajalich R. Combined treatment with Myo-inositol and Selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. J Thyroid Res. 2013;2013:424163.
[13] Nordio M, Basciani S. Treatment with Myo-Inositol and Selenium ensures euthyroidism in patients with autoimmune thyroiditis. Int J Endocrinol. 2017;2017:2549491.
[14] Höfling DB, Chavantes MC, Juliano AG, et al. Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial. Lasers Med Sci. 2013;28(3):743-753.; Höfling DB, Chavantes MC, Buchpiguel CA, et al. Safety and efficacy of Low-Level Laser Therapy in autoimmune thyroiditis: Long-term follow-up study. Int J Endocrinol. 2018;2018:8387530.
[15] Höfling DB, Chavantes MC, Juliano AG, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinol. 2012;2012:126720. doi:10.5402/2012/126720
[16]Höfling DB, Chavantes MC, Buchpiguel CA, et al. Safety and efficacy of Low-Level Laser Therapy in autoimmune thyroiditis: Long-term follow-up study. Int J Endocrinol. 2018;2018:8387530.
[17]Höfling DB, Chavantes MC, Juliano AG, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinol. 2012;2012:126720.
[18] Ganesh BB, Bhattacharya P, Gopisetty A, Prabhakar BS. Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity. J Interferon Cytokine Res. 2011;31(10):721-731. doi:10.1089/jir.2011.0049
[19] Kunnumakkara AB, Banik K, Bordoloi D, et al. Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Front Pharmacol. 2018;9:686. Published 2018 Aug 6. doi:10.3389/fphar.2018.00686
[20] Balkrishna A, Paliwal R, Maity M, Varshney Y, Sinha S, Varshney A. Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism – clinical phytoscience. SpringerOpen. June 20, 2024. Accessed March 28, 2025. https://clinphytoscience.springeropen.com/articles/10.1186/s40816-024-00371-0.
[21]Panda S, Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Phytother Res. 2005;19(1):78-80. doi:10.1002/ptr.1602
[22] Das G, Shin HS, Leyva-Gómez G, et al. Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Front Pharmacol. 2021;11:602364. Published 2021 Feb 8. doi:10.3389/fphar.2020.602364
[23] Huwiler VV, Maissen-Abgottspon S, Stanga Z, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34(3):295-313. doi:10.1089/thy.2023.0556
[24] Wei M, Ma W, Zhang W, et al. Efficacy and safety of Ophiocordyceps sinensis in the treatment of Hashimoto’s thyroiditis: a systematic review and meta-analysis. Front Pharmacol. 2023;14:1272124. Published 2023 Oct 3. doi:10.3389/fphar.2023.1272124
[25] He T, Zhao R, Lu Y, et al. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evid Based Complement Alternat Med. 2016;2016:1360386. doi:10.1155/2016/1360386
[26] de Oliveira GLV, Leite AZ, Higuchi BS, Gonzaga MI, Mariano VS. Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology. 2017;152(1):1-12. doi:10.1111/imm.12765; Virili C, Fallahi P, Antonelli A, Benvenga S, Centanni M. Gut microbiota and Hashimoto’s thyroiditis. Rev Endocr Metab Disord. 2018;19(4):293-300. doi:10.1007/s11154-018-9467-y
[27] Spaggiari G, Brigante G, De Vincentis S, et al. Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment. Front Endocrinol (Lausanne). 2017;8:316. Published 2017 Nov 14. doi:10.3389/fendo.2017.00316
[28] Virili C, Fallahi P, Antonelli A, Benvenga S, Centanni M. Gut microbiota and Hashimoto’s thyroiditis. Rev Endocr Metab Disord. 2018;19(4):293-300. doi:10.1007/s11154-018-9467-y
[29] Fröhlich E, Wahl R. Microbiota and Thyroid Interaction in Health and Disease. Trends Endocrinol Metab. 2019;30(8):479-490. doi:10.1016/j.tem.2019.05.008
[30] Kvantchakhadze R.G. Wobenzym® in the complex treatment of autoimmune thyroiditis. International Journal on Immunorehabilitation, 2002, Vol. 4, No. 1, pp. 114. [Czech abstract, Russian abstract] Research and Therapeutic Center of Rheumatology, Tbilisi, Gruzia. VIII. International Congress on Immunorehabilitation, Allergy, Immunology, and Global Net], April 21-24, 2002, Cannes, France.
[31] Nordio M, Basciani S. Efficacy of a food supplement in patients with hashimoto thyroiditis. J Biol Regul Homeost Agents. 2015;29(1):93-102.
[32] Hannan MA, Rahman MA, Sohag AAM, et al. Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients. 2021;13(6):1784. Published 2021 May 24. doi:10.3390/nu13061784
[33] Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016;16(1):471. Published 2016 Nov 16. doi:10.1186/s12906-016-1432-2
[34] Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012;31(4):268-274. doi:10.1080/07315724.2012.10720431
[35] Benvenga S, Ferrari SM, Elia G, et al. Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies. Nutrients. 2020;12(5):1337. Published 2020 May 8. doi:10.3390/nu12051337
[36] Brossaud J, Pallet V, Corcuff JB. Vitamin A, endocrine tissues and hormones: interplay and interactions. Endocr Connect. 2017;6(7):R121-R130. Published 2017 Aug 9. doi:10.1530/EC-17-0101
[37] Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018;7(9):258. Published 2018 Sep 6. doi:10.3390/jcm7090258; Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr. 2001;21:167-192. doi:10.1146/annurev.nutr.21.1.167
[38] Zubeldia JM, Nabi HA, Jiménez del Río M, Genovese J. Exploring new applications for Rhodiola rosea: can we improve the quality of life of patients with short-term hypothyroidism induced by hormone withdrawal?. J Med Food. 2010;13(6):1287-1292. doi:10.1089/jmf.2009.0286
[39] Ivanova Stojcheva E, Quintela JC. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. Molecules. 2022;27(12):3902. Published 2022 Jun 17. doi:10.3390/molecules27123902
[40] Liu Z, Li X, Simoneau AR, Jafari M, Zi X. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012;51(3):257-267. doi:10.1002/mc.20780
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