Over the past few years, my mission to help people recover from Hashimoto’s has become increasingly focused on using food as medicine (or food pharmacology) to address many of the root causes and symptoms of thyroid conditions. In addition to incorporating healing foods into my diet, I’ve also discovered many herbs and spices that can have profound benefits for healing. I’m always on the lookout for new research that could point us toward another tool to help us on our healing journeys.
Black seed oil has been on my radar for some time, especially since clinical trials started being published, revealing some possible benefits for those of us with Hashimoto’s thyroiditis. Some readers and clients in my community have asked about black seed oil, as they have heard about it being used for its medicinal properties and have been curious about it. One Root Cause Reset member recommended it for seasonal allergies. My curiosity was piqued, and I wanted to look into black seed oil and its effects on the thyroid, for my community.
Black seed oil has been touted as a “cure for everything except for death!”. I personally had a chance to use it myself twice in 2018, after the birth of my son. The first time I used black seed oil was to help support lactation. Black seed oil is an herb that is safe to use while breastfeeding. It’s actually considered a galactagogue, which means it can help to increase milk supply. [1]
Around four months after the birth of my son, I started to experience hair loss and new food sensitivities. I also found that my voice was becoming more hoarse. I tested my thyroid antibodies and they were elevated above 100 IU/mL — my Hashimoto’s was no longer in remission! (Under 100 IU/mL is considered in remission by many professionals.) While the antibodies weren’t as high as when I had started my journey (over 2000 IU/mL), I was concerned. I wasn’t sure if the Hashimoto’s was flaring up, or if it was postpartum thyroiditis. Luckily, I knew a thing or two about reducing Hashimoto’s antibodies and getting Hashimoto’s back into remission (the same principles apply to postpartum thyroiditis). 😉
At that point, I tested myself with the GI-MAP test (my favorite gut test) and found that I had H. pylori, a common trigger of Hashimoto’s and food sensitivities. [2] I was excited because I knew that treating this infection usually results in a reduction of thyroid symptoms and thyroid antibodies, but wasn’t sure about which protocol I would use, as many of the herbs I would typically use for H. pylori, are not safe to take while breastfeeding.
I reached out to my friend and colleague Dr. Maya Shetreat-Klein, and learned that black seed oil could be used against H. pylori. I used it along with propolis, and that did the trick — within a few weeks, my hoarse voice was gone, my hair stopped falling out, and my follow-up tests showed no more H. pylori. Even better, my thyroid antibodies were reduced! I also did another gentle protocol with black seed oil, to combat another H. pylori flare back in 2020. As such, I’ve been wanting to dig deeper into this wonderful herb and get the message out about its many benefits.
This article will explain how black seed oil, which has grown in popularity in the medical world, may be a game changer and get you one step closer to putting Hashimoto’s into remission. In this article, you will learn:
- What is black seed oil?
- The uses and benefits of black seed oil
- How black seed oil can impact thyroid hormone levels, fight gut infections, improve blood sugar levels, and balance cholesterol
- Black seed oil supplement recommendations
What is Black Seed Oil?
Black seed oil is derived from a plant that goes by many different names. Aside from its botanical name, Nigella sativa, it is also known as black cumin or black cumin seed. However, be careful not to confuse this plant with true culinary cumin (Cuminum cyminum), black pepper, black sesame, or black cohosh. The seeds are black on the outside and white in the middle, and produce a bitter taste.
Black seed oil is native to Southern Europe, North Africa, and Southwest Asia. Over time, it has spread further throughout the Middle East, where it is cultivated and carries with it a long history of religious and medicinal use. [3] The earliest archeological evidence suggesting cultivation, dates back to ancient Egypt and the tomb of Tutankhamen. It was also given credit for the beauty secret of Queen Nefertiti, who used black seed oil. Black seed oil is even mentioned in the Bible as the Hebrew “Ketzah,” a spice used in bread. Interestingly, the Arabic phrase for black seed oil, “Hibbatul barakah,” means “the seed of blessing.”
Black seed oil has likely been used as a medicinal herb for 3000 years or more, and its use has been documented in Ayurveda, Unani, Tibb, Siddha, and other systems of medicine. [4]
It has historically been used as a remedy for a variety of health conditions — most notably, for inflammation, cardiovascular health, infections, and skin issues. In addition to being used for vomiting, diarrhea, headaches, and the common cold, it was often prescribed as a tonic for general wellness.
Uses and Benefits of Black Seed Oil
Many of the medicinal properties of black seed oil are attributed to the compounds it contains, including thymoquinone (TQ), thymohydroquinone (THQ) and dihydrothymoquinone (DHTQ). The plant also contains many other active components, including thymol, alkaloids, saponins, and terpinenes.
The largest active component, TQ, makes up 30-48 percent of the essential oil of black seed oil, and offers the main biologic and pharmacologic effects. [5] Thymoquinone is an antioxidant and antihistamine. [6] It is also antimicrobial, antifungal and anti-inflammatory, and can modulate the immune system. It has been shown to protect the stomach lining, liver, kidneys and brain. Data shows TQ to have a low level of adverse effects and no serious toxicity.
Black seed oil also contains the antifungal compounds thymol and THQ.
The compounds found in black seed oil, which have been studied in animals and humans extensively, have also been found to protect the liver, kidneys, cardiovascular system, and gastrointestinal system. Furthermore, it has demonstrated antidiabetic, anticancer, and antiasthmatic properties.
Black Seed Oil Benefits for Hashimoto’s
Black seed oil shows promise for positively influencing thyroid health and lowering thyroid stimulating hormone (TSH). It may also play a role in addressing some of the individual root cause issues that contribute to Hashimoto’s, including gut health, blood sugar imbalances, and metabolic health. Let’s explore some of the recent evidence in further detail.
Thyroid Function
Although there is a lot of data on black seed oil, there had been little study in the Hashimoto’s population, until a 2016 Iranian study looked at the therapeutic use of black seed oil in people with Hashimoto’s thyroiditis. [7]
Participants between the ages of 22 and 50 received either 2 grams per day of black seed oil, or 2 grams per day of placebo, for eight weeks. Participants were also treated with levothyroxine from six weeks prior to the study, through the end of the trial.
At the beginning of the trial, there were no significant differences between the two groups. At the end of the eight week trial, the group receiving the black seed oil saw a reduction in weight, as well as in waist and hip circumference, compared to the placebo group.
During the trial, serum thyroid stimulating hormone (TSH) levels reduced from an average of 6.42 mIU/l to 4.13 mIU/l in the group receiving the black seed oil. Serum T3 also improved from an average of 0.92 mmol/l, to an average of 1.06 mmol/l. Both of these changes were statistically significant. (Anti-TPO antibodies were also reduced during the study, though this change was not considered to be statistically significant.)
This study also had a meaningful impact on Vascular Endothelial Growth Factor (VEGF), a protein that stimulates the formation of blood vessels and plays a specific role in the normal function and development of thyroid cells.
The study’s authors primarily attribute the positive changes to body composition and thyroid function to the anti-inflammatory and antioxidant properties of thymoquinone.
Since then, a slew of new studies have illustrated its potential uses and benefits for Hashimoto’s. Currently, black seed oil is one of the most cited plants being used for treatment of hypothyroid disorders. [8]
A 2020 study on patients with Hashimoto’s showed that treatment with black seed oil significantly increased total antioxidant capacity, which is important because those with Hashimoto’s typically have a lot of oxidative stress. [9] The study also showed that participants receiving the black seed oil saw a reduction in body mass and a reduction in LDL cholesterol, while HDL cholesterol levels improved.
Other recent studies have solidified black seed oil’s ability to improve thyroid hormones. A study conducted on hypothyroid rats in 2022 found that black seed oil raised T3 levels, and another study showed that a powder of black cumin seed was able to raise T3 levels over a period of eight weeks, while also reducing the synthesis of anti-TPO antibodies. [10] A 2020 study on hypothyroid rats showed that oral administration of black seed oil over four weeks was able to improve TSH levels. [11]
Black seed oil may also be protective for the livers and kidneys. In Hashimoto’s, impaired detoxification is a common issue, so this is another way in which we can support our systems. One study showed that TQ was able to restore normal liver function in hypothyroid rats who displayed nonalcoholic fatty liver disease. [12] Another study showed that TQ’s antioxidant properties may have a protective effect against hypothyroidism-induced kidney injury. [13]
Lastly, black seed oil has also been shown to have a gastroprotective effect on the formation of stress-induced gastritis. One study found that administration of black seed oil to rats over a period of 15 days showed a reduced number of ulcers and lesions in their guts. [14] The study attributed this to the antihistaminic effects of black seed oil, as well as its potent antioxidant effects. Supporting the gut is one of the most important things you can do for Hashimoto’s, as every person with Hashimoto’s will have some level of gut dysfunction.
I’m excited that so much new research is showing the benefits of black seed oil for Hashimoto’s. 🙂
Anti-Inflammatory
One way black seed oil can improve Hashimoto’s is through its anti-histamine properties. A component of black seed oil called “nigellone” can prevent the release of histamine from cells. [15] Not only does this help reduce inflammation-related conditions such as asthma and allergies, it also helps modulate autoimmune responses.
One study found that black seed oil can control allergic disorders through this mechanism (and also by decreasing inflammatory cells such as eosinophils, and inhibiting the IgE immune response). [16] The study also showed that this benefit was achieved without any signs or symptoms of noticeable toxicity.
The antioxidant effect of TQ is responsible for black seed oil’s anti-inflammatory properties. Not only does it preserve the activity of important antioxidants like glutathione, it also acts as a free radical scavenger itself. It has also been found that the flavonoids in black seed oil can enhance gastric mucus and strengthen the gut’s immune defense. [17] We know that healing the gut is an essential part of healing Hashimoto’s, so it’s always exciting to discover another way that we can support our healing.
Infections
Besides impacting the thyroid directly, black seed oil may play a role in addressing the root causes that contribute to Hashimoto’s thyroiditis, such as infections. (Often, infections can trigger autoimmune thyroid disease, and treating infections can help reverse the condition.)
Black seed oil is well demonstrated to have antibacterial properties. [18] It has been shown to inhibit the growth of Staphylococcusaureus, a cause of potentially life-threatening Staph infections that may be present in the imbalanced gut flora of people with autoimmunity. [19] The constituents TQ and melanin, found in black seed oil, may show promise in cases where an alternative to antibiotics is desired, or the bacteria has become resistant to antibiotics.
The antibacterial properties of black seed oil may also play a role in the treatment of H. pylori, a bacterial infection in the stomach that is common in those with Hashimoto’s. [20] TQ acts as a biofilm disruptor, meaning that it can break through the protective coating that H. pylori uses to protect itself, allowing antibacterial components to reach the H. pylori bacteria and eradicate the infection. I typically find that it works better in combination with other treatments, rather than a standalone for H pylori.
What’s more is that black seed oil has been shown to be gastro-protective in both human and rat studies. One rat study specifically looked at gastritis in rats with hypothyroid function and found that low thyroid function can be a trigger for gastritis. It also found that black seed oil can play a therapeutic role by inhibiting free radical generation and increasing levels of antioxidants that protect against oxidative stress in gastric tissue. [21]
Candida is another infection that may play a role in the development of Hashimoto’s. In this case, Candida is a fungus that can overgrow in the digestive system and other areas of the body. (Click here to read more about Candida and Hashimoto’s.) Given that the active constituents of thymol, TQ, and THQ in black seed oil are well known for their antifungal effects, black seed oil may be an antifungal option in the treatment of Candida. [22]
Along with its antibacterial and antifungal effects, black seed oil also has potent antiparasitic benefits. [23] It has been shown to eliminate parasites such as Trichomonas vaginalis, Schistosoma mansoni, Leishmania major, and Plasmodium yoelii. One study found that a preparation of black seed oil and alcohol was just as effective as metronidazole, a conventional antifungal medication, at eliminating Trichomonas vaginalis (the most common non-viral sexually transmitted disease). [24]
Many of the drugs that are typically used to treat parasites were developed many years ago, and some parasites have become resistant to them. This is why it’s been so important to find alternatives. A 2016 study found that TQ was able to eradicate 96.8 percent of Entamoeba histolytica and 96.62 percent of Giardia lamblia. For comparison, metronidazole only eradicated 70.9 percent of the parasites. [25]
As parasitic infections can also be a root cause of autoimmune thyroid conditions, black seed oil can support thyroid health for the long term, and be a beneficial supplement to add to your “medicine” cabinet.
Blood Sugar and Cholesterol Balance
Blood sugar imbalance, and even diabetes, are common co-occuring conditions in people with Hashimoto’s. [26] I often recommend stabilizing blood sugar as one of the first interventions when addressing your thyroid symptoms.
Black seed oil has demonstrated potential as an anti-diabetic agent and may play a supportive role in increasing insulin sensitivity (decreasing insulin resistance) in both animal and human studies. In a 3-month clinical trial with 94 diabetes patients, the black seed oil group experienced reduced blood sugar, both in fasting blood sugar and post-meal blood sugar. [27] A three-month average of the patients’ blood sugar (measured through hemoglobin A1C levels) also showed a significant reduction during the black seed oil trial period. Additionally, insulin resistance was reduced and beta cell function increased. (Beta cells are the cells in the pancreas that produce insulin.) The trial used dosages of 1, 2 and 3 grams of black seed oil per day, and found that the 2 gram per day dose was the most effective.
In a review of seven clinical trials, black seed oil showed promising results in improving glucose and lipids in type 2 diabetes. [28] Oftentimes, improvements in blood sugar go hand in hand with improvements in lipids, or cholesterol. This seems to be the case in the studies that have looked at metabolic health in relation to black seed oil.
A review of the data from the Iranian study regarding the use of black seed oil for Hashimoto’s uncovered that, not only did the trial group receive the benefits of lowered TSH and antibodies, as well as improved T4 to T3 ratio, weight, and anthropometric measurements (body composition), but they also saw an improvement in serum lipids. [29] In the study group, LDL cholesterol and triglycerides decreased, and HDL cholesterol significantly increased, compared to the group receiving the placebo over the 8-week trial. The study suggests that there are benefits to using black seed oil as an adjunct therapy in Hashimoto’s thyroiditis.
Side Effects/Precautions
The claims for the use of black seed oil are widespread and range from improving liver health to helping with asthma, as my Root Cause Reset participant suggested. Overall, black seed oil seems quite safe to use, with minimal side effects.
In the clinical trial of black seed oil with Hashimoto’s, nausea and itching were observed, and no other side effects were noted.
Please note, however, that black seed oil is processed through specific enzyme pathways in the liver and therefore, at least theoretically, could interact with medications that use the same pathways.
Furthermore, some formulas may not be safe for those with gallbladder issues. Additionally, black seed oil is an anticoagulant, or blood thinner, and shouldn’t be taken by those who have a bleeding disorder and/or are on medications that affect blood clotting.
It is always best to check with your doctor or pharmacist before beginning a new herbal supplement, to check for the possibility of interactions.
Black Seed Oil Supplements
Black seed oil supplements are available in a variety of forms that may be beneficial for different concerns. The most common therapeutic dose in the studies reviewed for this article was 2 grams per day. Human studies of black seed oil range from 8 weeks to 12 months of use. Safe doses go as high as 40 milligrams per kilogram of body weight. It is recommended to use black seed oil consistently for at least eight weeks before re-checking thyroid, blood sugar, or cholesterol lab work.
There are a few different ways you can take black seed oil:
- Liquid: Black seed oil itself can be taken orally in liquid form, such as this cold-pressed version from Kiva. Approximately ½ teaspoon contains a 2 gram dose. The oil can also be added to a carrier oil and massaged into the scalp for hair benefits, or applied directly to problem areas of the skin. I will say that it’s not the most pleasant tasting liquid, to say the least. 🙂 Most people who have tried it use the word “motor oil” to describe the taste, texture and smell. Please do not add it to your smoothies unless you want to ruin them, haha! #thingsIlearnedthehardway
- Powder: Nigella sativa powder is also available commercially. Look for ground black cumin seed options like this one. A 2 gram dosage can be measured with the scoop that is usually provided. Again, don’t add it to smoothies!
- Capsule: I was pleased to learn that Nigella sativa can also be utilized as a capsule, and so I created one for Rootcology. A capsule might be the easiest way to take black seed oil orally. I recommend Rootcology’s Black Cumin Seed Extract, which is combined with vitamin E for a synergistic effect to boost its anti-inflammatory properties. (Please note you should not take this product if you’re taking any of the following medications: alkylating agents, anticoagulant/antiplatelet drugs, antitumor antibiotics, blood thinners, cyclosporine, cytochrome P450 substrates (3A4), and/or selumetinib.)
Monitoring Your Thyroid Hormones When Taking Black Seed Oil
Whenever you start a lifestyle or complementary intervention to address Hashimoto’s, I encourage you to work with your doctor to monitor your thyroid symptoms, thyroid hormones, and thyroid antibodies. This is a great idea for any lifestyle intervention, but a must for lifestyle changes that could impact your TSH, like black seed oil, especially if you are already taking thyroid medications.
Studies have shown that black seed oil can impact thyroid hormones. In the Iranian study I’ve mentioned several times, TSH levels reduced from an average of 6.42 mIU/l to 4.13 mIU/l in the group receiving the black seed oil over a period of eight weeks.
This means that black seed oil could lower/normalize TSH in some cases, thus potentially reducing your requirement (or need) for thyroid meds. So as you move forward with supplementation, please look out for the following symptoms of being overmedicated: rapid or irregular heartbeat, nervousness, irritability or mood swings, muscle weakness or tremors, diarrhea, heat intolerance, menstrual irregularities, hair loss, weight loss, insomnia, chest pain, and/or excessive sweating.
I recommend testing thyroid hormone levels every six to 12 weeks while using complementary therapies, including root cause medicine, diet, or supplements, to ensure your thyroid medication dosage is optimized – or sooner, if you are showing any of the above symptoms. Thyroid medications are goldilocks hormones – they need to be used in just the right dose – and there are risk factors of being over-medicated.
Testing TSH, T4, T3, and the two most common Hashimoto’s antibodies, TPO and TG antibodies, is an important part of ensuring that the lifestyle changes you are making are both safe and helpful. 🙂 (You can read more about tests here.)
If your doctor is ordering these thyroid labs for you, be sure to request a copy so that you can see them for yourself and ensure that they are interpreted correctly. If you aren’t able to use your physician for ordering, or have a high deductible insurance plan like I do, you may also wish to self-order your own thyroid monitoring labs. I recommend the Ulta Labs thyroid panel for monitoring your progress, which can be ordered anywhere in the U.S. (some, but not all, insurance companies may reimburse you for self-ordered labs, so please be sure to check with your plan).
Takeaway
I find black seed oil to be incredibly interesting, with an intriguing history and science behind it. It holds promise as one piece of the thyroid health puzzle, in its ability to balance thyroid hormones, treat infections, and stabilize blood sugar and cholesterol. If I come across any other important studies, I will be sure to write about them on this blog.
For more information regarding addressing your personal root causes of Hashimoto’s, see my book Hashimoto’s Protocol, and for recipe ideas that are thyroid supportive, check out my cookbook Hashimoto’s Food Pharmacology: Nutrition Protocols and Healing Recipes to Take Charge of Your Thyroid Health. If you believe your adrenals are part of your Hashimoto’s root causes, I’d also recommend checking out my newest book, Adrenal Transformation Protocol.
I wish you all the best on your healing journey!
Now I’d love to hear from you. Have you tried a black seed oil supplement? If so, what has been your experience?
P.S. You can download a free Thyroid Diet Guide, 10 thyroid-friendly recipes, and the Nutrient Depletions and Digestion chapter of my first book for free by signing up for my newsletter. You will also receive occasional updates about new research, resources, giveaways, and helpful information.
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References
[1] Foong SC, Tan ML, Foong WC, Marasco LA, Ho JJ, Ong JH. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. Cochrane Database Syst Rev. 2020;5(5):CD011505. Published 2020 May 18. doi:10.1002/14651858.CD011505.pub2
[2] Shmuely H, Shimon I, Gitter LA. Helicobacter pylori infection in women with Hashimoto thyroiditis: A case-control study. Medicine (Baltimore). 2016;95(29):e4074. doi:10.1097/MD.0000000000004074
[3] Ahmad A, Husain A, Mujeeb M, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337-352. doi:10.1016/S2221-1691(13)60075-1
[4] Ijaz H, Tulain UR, Qureshi J, Danish Z, Musayab S, Akhtar MF, Saleem A, Khan KK, Zaman M, Waheed I, Kahn I, Abdel-Daim M. Review: Nigella sativa (Prophetic Medicine): A review. Pakistan Journal of Pharmaceutical Science. 2017; 30(1): 229-234
[5] Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. Pharmacological Research. 2015; 95-96: 138-58. doi: 10.1016/j.phrs.2015.03.011
[6] Khader M, Eckl PM. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014;17(12):950-957.
[7] Farhangi M, Dehghan P, Tajmiri S, Abbasi M. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF)-1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial. BMC Complementary and Alternative Medicine. 2016; 16: 471. doi: 10.1186/s12906-016-1432-2
[8] Taïbi K, Ait Abderrahim L, Helal F, Hadji K. Ethnopharmacological study of herbal remedies used for the management of thyroid disorders in Algeria. Saudi Pharm J. 2021;29(1):43-52. doi:10.1016/j.jsps.2020.12.004
[9] Farhangi MA, Tajmiri S. The effects of powdered black cumin seeds on markers of oxidative stress, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimoto’s thyroiditis. Clin Nutr ESPEN. 2020;37:207-212. doi:10.1016/j.clnesp.2020.02.015
[10] Avci G, Ulutas E, Ozdemir V, Kivrak I, Bulbul A. The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones in rats with hypothyroidism and hyperthyroidism. J Food Biochem. 2022;46(4):e13801. doi:10.1111/jfbc.13801; Farhangi MA, Tajmiri S. The effects of powdered black cumin seeds on markers of oxidative stress, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimoto’s thyroiditis. Clin Nutr ESPEN. 2020;37:207-212. doi:10.1016/j.clnesp.2020.02.015
[11] Nasr El-Din WA, Abdel Fattah IO. Histopathological and biochemical alterations of the parotid gland induced by experimental hypothyroidism in adult male rats and the possible therapeutic effect of Nigella sativa oil. Tissue Cell. 2020;65:101366. doi:10.1016/j.tice.2020.101366
[12] Ayuob NN, Abdel-Hamid AAHM, Helal GMM, Mubarak WA. Thymoquinone reverses nonalcoholic fatty liver disease (NAFLD) associated with experimental hypothyroidism. Rom J Morphol Embryol. 2019;60(2):479-486.
[13] Ayuob N, Balgoon MJ, El-Mansy AA, Mubarak WA, Firgany AEL. Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats. Oxid Med Cell Longev. 2020;2020:3295831. Published 2020 Jul 20. doi:10.1155/2020/3295831
[14] Abdel-Sater KA. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol. 2009;1(2):143-149. Published 2009 Mar 10.
[15] Ahmad MF, Ahmad FA, Ashraf SA, et al. An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties. J Herb Med. 2021;25:100404. doi:10.1016/j.hermed.2020.100404
[16] Shahzad M, Yang X, Raza Asim MB, et al. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther. 2009;22(1):37-43. doi:10.1016/j.pupt.2008.11.006
[17] Ahmad MF, Ahmad FA, Ashraf SA, et al. An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties. J Herb Med. 2021;25:100404. doi:10.1016/j.hermed.2020.100404
[18] Forouzanfar F, Bazzaz BS, Hosseinzadeh H. Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects. Iran J Basic Med Sci. 2014;17(12):929-938.
[19] Bakathir HA, Abbas NA. Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Complement Altern Med. 2011;8(2):159-164. doi:10.4314/ajtcam.v8i2.63203
[20] Salem EM, Yar T, Bamosa AO, et al. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol. 2010;16(3):207-214. doi:10.4103/1319-3767.65201
[21] Abdel-Sater KA. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. International Journal of Physiology, Pathophysiology and Pharmacology. 2009; 1(2); 143-149.
[22] Shokri H. A review on the inhibitory potential of Nigella sativa against pathogenic and toxigenic fungi. Avicenna J Phytomed. 2016;6(1):21-33.
[23] Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F. Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses. Evid Based Complement Alternat Med. 2019;2019:1528635. Published 2019 May 12. doi:10.1155/2019/1528635
[24] Aminou HA, Alam-Eldin YH, Hashem HA. Effect of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin on the ultrastructure of Trichomonas vaginalis trophozoites. J Parasit Dis. 2016;40(3):707-713. doi:10.1007/s12639-014-0564-x
[25] Sheikh BY, Taha MME, Koko WS, Abdelwahab SI. Antimicrobial effects of thymoquinone on Entamoeba histolytica and Giardia Lamblia. Pharmacognosy Journal. https://phcogj.com/article/145. Published 2016. Accessed December 7, 2022.
[26] Mouradian M, Abourizk N. Diabetes mellitus and thyroid disease. Diabetes Care. 1983;6(5):512-520. doi:10.2337/diacare.6.5.512
[27] Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian Journal of Physiology and Pharmacology. 2010;54(4):344–354.
[28] Daryabeygi-Khotbehsara R, Golzarand M, Ghaffari MP, Diafarin K. Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis. Complementary Therapies in Medicine. 2017; 35: 6-13. doi: 10.1016/j.ctim.2017.08.016
[29] Farhangi M, Dehghan P, Tajmiri S, Abbasi M. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF)-1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial. BMC Complementary and Alternative Medicine. 2016; 16: 471. doi: 10.1186/s12906-016-1432-2
Note: Originally published in August 2019, this article has been revised and updated for accuracy and thoroughness.
The Life Extension product says do not take if you have gall bladder problems or gall stones. What if you have no gall bladder?
Cynthia – thank you for reaching out. <3 Please understand, I am not able to advise on whether the Life Extension black seed oil supplement would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor. <3
Can you cook with black seeds, like you would with cumin after grounding into powder?
Tameka – thank you for reaching out. Yes, you can add this to your foods. Check out the article above near the bottom for my product recommendations. <3
Any thoughts on why 2 grams was more effective than 3 grams?
Do you think that combining with honey increases its effectiveness in treating H. Pylori?
Thanks for always being an excellent health resource!
Ariana
Ariana – thank you for reaching out. Great question! I cannot say how effective 3 grams would have been as the study was done using 2 gram. I am also not able to comment on the effacacy if combined with honey. Black seed oil has an incredible history behind it. It holds some promise with thyroid health in its ability to balance thyroid hormones, treat infection, and stabilize blood sugar and cholesterol. I am hoping to see more research on this topic in the coming years.
After reading this article last night, I remembered I had bought black cumin seed oil a few months ago and had it in my pantry. I had 1 tsp, hoping it would help my possible Hashis flareup where my hair is noticeably thinning the last month. Imagine my horror this morning when I noticed a worm-like thing in the toilet (sorry!). I wondered if the black cumin seed oil might be the reason, so I googled it and found it is known for its anti-parasitic use, especially to rid the human body of worms. Eeek. Just 1 tsp could do that?? Thought I’d pass it on. Its something I wasn’t expecting!!
Kathy – thank you so much for sharing. <3
Kathy, curious if it ended up helping your hair/blood levels?
I appreciate your article on black seed oil. How many Life Extensions capsules would have to be taken daily to reach the 2 gram dose that seems to be most effective?
Margaret – thank you for reaching out. <3 Please understand, I am unable to answer specific medical questions, without a comprehensive health assessment. I recommend that you discuss this with your personal doctor. For specific questions on how and when to take particular supplements under normal circumstances, please do reach out to my team by email, they will be more than glad to help 🙂
Thank you got this information. Please can you tell me why when ever I eat anything now ( it use to be just wheat, bread etc) but now it’s ANYTHING I eat , after half an hour my stomach bloats out from under my breasts & I look 9 months pregnant. Is there anything I can do or take for this.? I am 64 years old with high cholesterol & find its so easy to put on weight! Please can you help me. Thank you . Sheralyn Taylor.
Sheralyn – thank you for reaching out. I am so sorry you are struggling with this. <3 My heart goes out to you. We know that intestinal permeability (aka leaky gut) is present in every case of autoimmunity and often precedes the development of Hashimoto’s. Symptoms of leaky gut may include bloating, diarrhea, constipation, stomach aches, acid reflux and irritable bowel syndrome. According to the Institute of Functional Medicine, many people develop IBS 5-10 years before an autoimmune diagnosis. I was one of them and didn’t take my gut health as seriously as I should have. Gut problems are often caused by infections like H. pylori, parasites like Blasto, SIBO, an imbalance of bacteria, and enzyme deficiencies or food sensitivities (especially to gluten, dairy, and/or soy). Even stress can be a factor in gut permeability. Here is an article you might find interesting.
6 DIFFERENT ROOT CAUSES
https://thyroidpharmacist.com/articles/6-different-hashimotos-root-causes/
Could you recommend another brand of liquid? Oakmont Labs does not appear to be available anywhere. Thanks so much!! 🙂
Patti – thank you for reaching out. Please email my team at info@thyroidpharmacist.com and they will be happy to help you. <3
Hi,
I have mild psoriasis on my scalp and I have been using Black Seed oil for about 6 months.
Every second day (on the day I shampoo) I rub the oil liberally on and through my scalp/hair (leave min. 2 hours) and I no longer have psoriasis!
Also, my hair is moisturised and soft!
I have a dodgy thyroid (no meds yet) so will start taking orally also
Thank you, Sally
Sally – thank you so much for sharing what has worked for you! <3
Sally Hordern, this is exciting news about scalp psoriasis. So glad you found a remedy! Do you use the oil straight or with a carrier? – Pat Porter
Thank you for this great information! I was just wondering how much of black seed oil you recommend for an H. pylori infection.
Agnes – thank you for reaching out. <3 Please understand, I am not able to advise on whether this supplement would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor.
Thank you for this great post! I love nigella sativa, we sprinkle it on top of our traditional bread usually. How would you recommend taking? With meals or on empty stomach! Thank you
Camilla – thank you for reaching out. You should start with the directions on the bottle and adjust your dosage from there. <3 Please understand, I am unable to answer specific medical questions, without a comprehensive health assessment. For specific questions on how and when to take particular supplements under normal circumstances, please do reach out to my team by email, they will be more than glad to help 🙂
If this product could cause Cancer (black seed oil ) why producing it and sell to patients? Is that not unethical? As l much as l like what the Supplements can do to heal the patient, l am afraid of the side effects which is Cancer. Thank you.
Patricia .
Nigeria.
Buraimoh – thank you for reaching out. In the Black Seed Oil article above it states “The compounds found in black seed oil, which have been studied in animals and humans extensively, have also been found to protect the liver, kidneys, cardiovascular system, and gastrointestinal system. Furthermore, it has demonstrated antidiabetic, anticancer, and antiasthmatic properties. I hope this helps. If you have any other questions please feel free to email my team at info@thyroidpharmacist.com and they will be happy to help you. <3
Hi Dr Izabella
Regarding The dosage that u used to treat H-pylori
I’m assuming it’s also
2 grams for 8 weeks ?
Thx for sharing ur experience:)
Joju – thank you for reaching out. Please understand, I am not able to advise on the black seed oil dosage that would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor. Here is an article you might find helpful as well:
HASHIMOTO’S AND GRAVES’ REMISSION AFTER HELICOBACTER PYLORI ERADICATION
https://thyroidpharmacist.com/articles/hashimotos-and-graves-remission-after-helicobacter-pylori-eradication/
What is this oil supposed to taste like. I have some and it tastes like fuel oil smells. Awful!
Janette – thank you for sharing. I am so sorry. It does have a bitter taste. You may want to check with the company that you purchased if from and see what their recommendation would be. <3
If one has gallstones, is there also a concern with using the powder or the oil, or is it only a concern with the Life Extension supplement?
Frances – thank you so much for reaching out. I am not able to advise on whether the powder or oil versions of the black seed oil would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor. <3
Hi Izabella
I’ve been taking 2 gramms of black cumin seeds for 2 months
My TSH was 2,87, TGab 4,3, AT-TPO 305,7 before I started
Now TSH is 2,84, TGab 3,2, AT-TPO 214
Hope it will encorage some of your readers
Vera – thank you so much for sharing what has worked for you! <3
What form are you taking?
On an emty stomach ??
Did it raise your FT3 as well? Your FT4? Thanks!!
Hi Dr. Wentz,
I bought a bottle of black seed oil after reading this but then I remembered that I have borderline low blood pressure. Is it safe for me to take as I read that black seed oil helps to lower blood pressure.
Kim – thank you for reaching out. <3 I am not able to advise on whether black seed oil would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor.
Thank you for reminding us to think about what we are putting into our bodies. I have had a variety of health challenges from childhood and was diagnosed with Hashimotos Thyroiditis after being tested for Lupus. Eliminating MSG from my diet has helped a great deal. Presently, I have one kidney remaining at stage 3 CKD. I am thinking the oil might be a welcome addition to my life plan. I will speak to my D.O. and hope to write a positive update in a few months so that I can continue my work through the nonprofit I started but stalled during the loss of my kidney & current battle. I have a lot of living to do! Thank you for all you do.
Tricia – thank you so much for sharing your journey! <3 I'm looking forward to seeing your progress.
Thank you for this very informative article. I was on a Neem protocol for Candida overgrowth. After adding 2-3 grams of ground black seeds to my daily routine, I noticed the Neem having more effect. I have not re-tested yet, so not sure what the results will be.
I did choose to freshly grind my black seeds (in a coffee grinder) to avoid the risk of seed oil becoming rancid. But, from your article, it seems that is not a concern?
Great article! I tried this supplement about a year ago and so wanted to like it, but it seemed to throw my body off-balance. I started having hormone symptoms like night sweats. Any idea why that might be? (I’m on HRT for medical menopause.)
Kelley – thank you so much for your support! <3 I am so sorry you did not have a good experience with the black seed oil. Black seed oil is processed through specific enzyme pathways in the liver and therefore, at least theoretically, could interact with medications that use the same pathways. It is always best to check with your doctor or pharmacist before beginning a new herbal supplement, to check for the possibility of interactions.
Hi Dr. Izabella
I have 3 questions. I know this oil is suppose to balance your blood sugar, but will it balance your blood pressure as well to be within normal limits whether your blood pressure is usually high or low? Also, I have read that this oil is good for those with RA and thyroid issues, but do you know if this helps with other autoimmune diseases such as lupus, MS or any connective tissue disorder? I only say this because my doctor says its best to suppress the immune system, but was wondering if black seed oil will do the opposite. He’s never heard of this oil. Lastly, it says that it can protect your organs like your kidney, does this mean preventing kidney stones from forming?
Thank you.
Jocelyn – thank you for reaching out. <3 Please understand, I am not able to advise on whether the Black Seed oil would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor.
Thymoquinone sounds a lot like the bad medicines like Cipro and the other fluroquinones.
Please assure me that there is no relationship between Thymoquinone and the fluoroquinones.
Mary – thank you for reaching out. The fluoroquinolones contained in Cipro are man made product created using fluoride. Here is an article that you may find helpful: https://thyroidpharmacist.com/articles/9-medications-toxic-thyroid/
Do caraway seeds have the same benefit?
Karen – thank you for reaching out. <3 I don’t currently have information to share on caraway seeds but, I will add it to my list of possible future articles to research.<3
If you have chemical or peripheral neurothophy, will this oil help with the pain? If you are on pain meds, should you stop your pain meds before taking the Black Seed oil ?
Janie – thank you so much for reaching out. <3 Please understand, I am not able to advise on whether the Black Seed oil supplement would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor.
I have read your articles and would
Like to know which is the best black sédeme oil ! Thank you for all your advice
Mara – thank you for reaching out! <3 Scroll towards the bottom of this Black Seed Oil article and you will find my recommendations.
I HAD A COMPLETE THYROIDECTOMY BECAUSE OF A LARGE GROWTH. I AM TAKING LEVOTHYROXINE AND MY TESTS ARE ALWAYS GOOD ACCORDING TO MY DR. I STILL HAVE ALL THE SYMPTOMS THAT I HAD BEFORE THE SURGERY! I HAVE ASKED MY DR, TO LET ME TRY A DIFFERENT MEDICATION BUT HE IS NOT INTERESTED! SINCE I HAVE NO THYROID, IS THERE ANT HELP FOR ME?
Margaret – thank you so much for following this page. <3 There are quite a few options for thyroid medications. In my experience, what works for one person may not work for another. If your doctor will not prescribe the medication which you are looking for, ask your local pharmacist for doctors in your area who prescribe the medication you are looking to try. Have you read these articles?
WHICH THYROID MEDICATION IS BEST?
https://thyroidpharmacist.com/articles/which-thyroid-medication-is-best/
TOP 11 THINGS YOU NEED TO KNOW ABOUT THYROID MEDICATIONS
https://thyroidpharmacist.com/articles/top-11-things-you-need-to-know-about-thyroid-medications/
Did you know most thyroid conditions result from the immune system attacking the thyroid because the immune system is out of balance? Even when the thyroid is taken out surgically or treated with radioactive iodine the autoimmunity still persists in most cases. Many people will have their thyroids removed, and will develop new autoimmune disorders such as Lupus, Rheumatoid arthritis, etc. The immune system just finds a different target. We need to rebalance the immune system to prevent this. Sometimes the autoimmunity can be reversed as well! The gut determines your immune system. With the exception of discussing proper thyroid medication dosing, the majority of my website and my book focuses on balancing the immune system. The info I present is based on my own research and journey for overcoming my autoimmune thyroid condition. Here are the links to my books:
Hashimoto’s Root Cause
http://amzn.to/2DoeC80
Hashimoto’s Protocol
http://amzn.to/2B5J1mq
I take Armor thyroid replacement meds. 5 days a week 150 mm and 2 days I take 120 mm will the Black pepper oil interfer with my meds
Thank you for your time.
Sharon – thank you for reaching out. <3 Please understand, I am not able to advise on whether the Black Seed oil would be appropriate for you and your specific health needs without a comprehensive health assessment. I recommend that you discuss this with your personal doctor or pharmacist.
Is it safe for children to use as well?
Stephanie – thank you for reaching out. <3 Most of the interventions recommended in my book and website can be done with children, with the exception of the dosing of supplements. I do suggest that you work with a functional medicine doctor that is familiar in working with children (I only works with adults). I hope this helps!
FUNCTIONAL MEDICINE APPROACH TO THE THYROID
https://thyroidpharmacist.com/articles/functional-medicine-approach-to-the-thyroid
CLINICIAN DATABASE
https://thyroidpharmacist.com/database-recommended-clinicians/
FIND A FUNCTIONAL MEDICINE CLINICIAN
https://www.functionalmedicine.org/practitioner_search.aspx?id=117
Will Black Seed Oil affect lab results? If so, how long should one wait, after stopping, before having labs drawn?
Lynn – thank you for reaching out. <3 Black seed oil is processed through specific enzyme pathways in the liver and could interact with medications that use the same pathways. It is always best to check with your doctor or pharmacist before beginning black seed oil to check for the possibility of interactions.
Hi Dr. Wentz, thank you for this article. I am wondering if Black Cumin Seed Oil has been known to lower TgAb or just TPO antibodies? I have only been able to find mention of TPO in my research and in your article, and I have high TgAb antibodies as opposed to TPO.
Thank you very much.
Hallie, thank you so much for reaching out! ❤️ I don’t currently have information to share on Black Cumin Seed oil but, I will add it to my list of possible future articles to research.
Thank you for your article! I have been taking 100mcg of Synthroid for over 8 years, but after 3 months of taking 1 tsp of black seed oil per day, I now only require 25mcg. My question is, are you still taking the oil? I’m finding very little information on taking it beyond that time frame.
Collinjenn – That’s great to hear! <3 Dosing recommendations may vary between individuals. I recommend working with a practitioner to help you determine the best course of action for your needs. <3
Dr. Where this black seed oil can be get it and what is the dosis to be taken, thank you!
Marcia – thank you for following. If you check out the article above I share my recommendations there. ❤️
Dr Wentz,
Thank you for this pertinent article at this time. I was just looking for something regarding Blackseed oil and Hashimoto’s. I was just looking for something regarding Blackseed oil and Hashimoto’s. Just a question and caveat… I was wondering if you had found in your studies if it was safe to take during pregnancy since it is safe to take when breast-feeding. Thank you so much.
Kerri
Kerri – thank you for reaching out. ❤️ I do not recommend Black Seed oil supplement while pregnant or nursing, as these things have the potential to pass through to the baby. That is not to say that they are necessarily unsafe, but I have not specifically researched the supplements’ effects on pregnancy, so I am not be able to confirm their safety.
Just fyi for those with hypothyroid hair loss, did a bit of research on black seed oil recently and came across an article f detailing findings that it significantly reduces VEGF. I looked into this and turns out it is a growth factor that plays a notable role in the hair growth. Isabella, would be interested in your thoughts on this if any. In any case, something additional to consider. I used to make tea from black cumin seeds but stopped.
S.M. – thank you so much for sharing. ❤️ I don’t currently have information to share on this connection but, I will dig into that and share my findings in a future blog post!
Can you take the black seed oil if you had a throidectomy?
Daphne – thank you for reaching out. I recommend discussing any supplement additions with your practitioner to be sure they are an option for you.
First, thank you for your commitment and this website. I am lucky as the blackseed oil can be found in my country on every step (cold served ) I have Hypothyroidism Hashimoto for 6 years, on therapy. Under control. Unfortunately I have problems with lipids level. Started using black seed oil 10 weeks ago, results are : from LDL 5.0 to 3.7, HDL from 1.1 to 1.3 and total cholesterol from 6.1 to 5.0, TSH is now 1.4, it was even with therapy ( 25mg/50mg ) around 2 and FT4 is now 15 it was 17.
I feel better, I missed all flus, and infections during this winter so far.
Great choice listening your advice.
THANK YOU !!!
Tarik – My pleasure! Thank you so much for sharing!
I’ve recently started taking black cumin seed oil and will be interested if it helps me, I have hypothyroidism and don’t respond well to meds, so I’m hoping to find an alternative method of support. If I do feel the benefit, do I need to carry on taking it ongoing, like you would thyroid meds? Or do I then stop taking it, once I feel better?
Helen – thank you for reaching out. Black Cumin Seed Extract can be taken for three months to two years.
I started taking black seed oil about a year ago, although not regularly. My endo had told me that I was prediabetic. Who isn’t right? I found that if I take black seed oil the previous day, my blood glucose is in the 80’s rather than high 90’s the next day. I believe it also affects my blood pressure. I was told I had “White coat syndrome”. I was really stressed going to my last Endo appointment due to getting results of my ultra sound. And I had a cup of coffee on the way to the appointment. I was surprised when the nurse said, “Great Blood Pressure today, 120/70. I made her take it again. It also seemed to reduce my Tg antibodies,(20 down to 4) but not so much TPO (although that is only given in a range). I really would caution taking it if you are on diabetic meds or blood pressure meds.
Jane – Thank you so much for sharing your journey!
I tried the black cumin seed oil a few years back as it had been touted as being good for one’s overall health. Absolutely did not like the taste and after about three days it actually made me throw up almost instantly after consumption. Had since heard that it should be taken with food but now if I even smell it, it makes me gag. I have Hashimoto’s and would love to get my levels in the normal range but both my nose and stomach won’t tolerate it! 😛
Melinda – I’m so sorry! Have you considered the capsule form? There are also other things that you can do to get your levels in normal range. Here are a couple links that might help:
WHERE DO I START WITH HASHIMOTO’S
https://thyroidpharmacist.com/articles/where-do-i-start-with-hashimotos/
OVERCOMING HASHIMOTO’S
https://thyroidpharmacist.com/articles/overcoming-hashimotos-in-the-new-year
Hi! I’ve been taking blackseed oil for two months now. Within ten days the symptoms of my ulcerative colitis where gone. After aprox 1 1/2 month I started to noticed that the inflammation in my joints was much lower (I have RA) and less fatigue. I’m taking the unfiltered oil. I started with 1 tsp the first week morning and evening, then incressed to 1 tbsp (twice a day). I’m taking it with warm water or tea, that way the oil taste is no problem. Aprox 3 weeks after I started with the oil I got itching over my body. I suspect it was some kind of reaction. I continued with the oil, but in lower dosage. The itching stopped. Then I increased the dosage again ( now I’m taking ca. 2/3 of a tbsp, twice a day. Still, no symptoms of the colitis and almost no inflammations in my joints (only in one foot). So, this is my experience after two months.
Mimmi – That’s amazing! Thank you so much for sharing.
Hi, in the context of black cumin oil helping with Trichonoma vaginalis , is this achieved through oral or vaginal administration ?
Kat – thank you for reaching out. The forms I recommend in the article are for oral use.
Does Black seed oil interact with Hydroxychloroquine?
Have chemicals been used in the extraction of the oil? Perhaps this is why it tastes so bad?
Jane – thank you for sharing. It does have a bitter taste. I do recommend a organic cold-pressed version and you could also contact the company you are considering purchasing from to find out more specifics on how they extract their oil.