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If you’ve ever struggled with brain fog, anxiety, or energy crashes (especially with Hashimoto’s), you’re not alone — and you’re definitely not imagining it. I’ve been there. At the height of my health struggles, I went from feeling sharp and energized to constantly forgetting words, losing my train of thought, and dragging myself through the day. Even after getting on thyroid medication, something still felt off. What I didn’t know at the time was that the root of it all might have been hiding inside my cells: mitochondrial dysfunction.
In this episode of the Thyroid Pharmacist Healing Conversations podcast, I spoke with Dr. Scott Sherr, an internal medicine physician and pioneer in mitochondrial and brain optimization. He shared powerful insights on how mitochondrial health plays a central role in energy production, detoxification, mood, and even hormone regulation — and how tools like methylene blue, hyperbaric oxygen, and GABA support can transform the way you feel.
What you’ll learn in this episode:
- The hidden role of mitochondrial dysfunction in brain fog, fatigue, and poor focus — and why it’s not just a concern for those with chronic illness. Dr. Scott Sherr breaks down how these tiny powerhouses affect your energy, mood, and even cognitive clarity.
- A surprising ally in brain and mitochondrial support: methylene blue. Learn how this centuries-old compound is gaining new life in functional medicine — and why timing, dose, and delivery make all the difference.
- What you need to know before trying methylene blue — including safety considerations, medication interactions, and red flags to watch for. Dr. Sherr offers a science-backed, practical guide to smart use.
- Why anxiety and low mood may not just be psychological — but biochemical. We explore how GABA, a calming neurotransmitter, is impacted by gut health, nutrient status, and chronic stress, and how you can start restoring balance naturally.
- When hyperbaric oxygen therapy (HBOT) might be the missing piece in your healing puzzle. Discover how this powerful therapy can boost mitochondrial function, reduce inflammation, and support long-term brain and nervous system health.
Guest Resources/Connect with Dr. Scott Sherr
- Dr. Sherr’s companies: Troscriptions, HOMeHOPe, OneBase
- Personal consulting: HOMe-SF
- Hyperbaric consultations: Integrative HBOT
- Instagram: Dr Scott Sherr, Troscriptions, HOMeHOPe, OneBase
- Smarter Not Harder podcast on YouTube
- Troscriptions on YouTube
- Dr. Sherr on X
- Troscriptions on X
Supplements We Discussed
- Troscriptions Methylene Blue: Supports mitochondrial energy production and may enhance cognitive function and endurance. (Use code DRWENTZ for 10% off any order placed on the website!)
- Troscriptions Tro Calm: Includes nicotinoyl-GABA, and synergistic ingredients to support calm without sedation.(Use code DRWENTZ for 10% off any order placed on the website!)
- Troscriptions Tro ZZZ: Includes GABA to help with relaxation and support sleep. (Use code DRWENTZ for 10% off any order placed on the website!)
- Troscriptions Blue Cannatine: A blend of methylene blue, nicotine, caffeine, and other ingredients for focus and brain fog. (Use code DRWENTZ for 10% off any order placed on the website!)
- Benfotiamine: Supports mitochondrial health and energy metabolism. Use “PODCAST” to get 20% off Rootcology Benfotiamine.
- Vitamin B6 and Magnesium: Required to convert glutamate into calming GABA.
Other Tools and Resources
- Organic Acids Testing: Helps assess mitochondrial health, nutrient status, and detox function.
- Red Light Therapy: Synergistic with methylene blue for enhanced mitochondrial function.
- Matcha + Methylene Blue Protocol: Hot matcha tea may help reduce blue staining in the mouth, according to Dr. Wentz’s experiments. Also delicious and full of antioxidants! 🙂
- Buffered Vitamin C: Useful for cleaning up methylene blue spills, according to Dr. Scott!
Books and Articles About Mitochondrial & Thyroid Health
- Adrenal Transformation Protocol by Dr. Izabella Wentz
- The Mitochondria, Adrenal, and Thyroid Connection
- Hashimoto’s Winter Survival Guide
- Self-Care Resources for Adrenal Healing
- Brain Fog and Hashimoto’s
- Strategies to Overcome Anxiety with Hashimoto’s
- 11 Strategies to Overcome Hashimoto’s Fatigue
- Are Your Adrenals Sabotaging Your Health?
- Can Thiamine Help Reduce Thyroid Fatigue?
- Vitamin B6 and Hashimoto’s
- Studies on Magnesium and Thyroid Health
Get the Full Episode Transcript
Let’s Connect!
- Follow me on Instagram:@izabellawentzpharmd
- Get my FREE weekly thyroid & gut health newsletter: Sign up here
- Subscribe & Review: If you loved this episode, please leave a review on Apple Podcasts or Spotify!
If this podcast resonates with you, don’t forget to share with a friend who needs this information!
Got questions? Drop them in the comments! 🙂
About Our Host
Dr. Izabella Wentz
Dr. Izabella Wentz is a compassionate, innovative, solution-focused integrative pharmacist dedicated to finding the root causes of chronic health conditions. Her passion stems from her own diagnosis of Hashimoto’s thyroiditis in 2009, following a decade of debilitating symptoms.
Dr. Izabella Wentz has written several best-selling books, including the New York Times bestseller Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause, the protocol-based #1 New York Times bestseller Hashimoto’s Protocol: A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back, the Wall Street Journal bestseller Hashimoto’s Food Pharmacology: Nutrition Protocols and Healing Recipes to Take Charge of Your Thyroid Health, and her latest book, Adrenal Transformation Protocol.
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About Our Guest
Dr. Scott Sherr is a Board Certified Internal Medicine Physician certified to Practice Health Optimization Medicine (HOMe) and is also a Hyperbaric Oxygen Therapy (HBOT) specialist. He is also the COO of Troscriptions, a line of physician formulated, pharmaceutical grade, and precision-dosed buccal troches containing novel ingredients like methylene blue, agaric, and others in formulas for energy, focus, sleep, stress, immune support, and more. Additionally, he serves as VP of Health Optimization Medicine and Practice (HOMe/HOPe), the nonprofit arm of Troscriptions which trains practitioners on optimizing health rather than treating disease, as well as the Chief Medical Officer of OneBase Health, a company building software and hardware to power and integrative technology, including hyperbaric chambers, lights, saunas, and more.
His clinical practice includes HOMe as its foundation, plus an integrative approach to hyperbaric oxygen therapy that includes cutting-edge and dynamic HBOT protocols, comprehensive laboratory testing (using the HOMe framework), targeted supplementation, personal practices, synergistic technologies (new and ancient), and more.
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